The transient protein expression market size is projected to reach US$ 1,320.38 million by 2031 from US$ 836.68 million in 2023. The market is expected to register a CAGR of 5.9% during 2023–2031. Expanded application range of protein expression systems, including applications in the field of precision medicine, owing to the integration of artificial intelligence (AI) and automation technologies in protein expression workflows to enhance the efficiency, accuracy, and scalability of the overall process is likely to remain a key trend in the market.
Transient Protein Expression Market Analysis
The increasing applications of protein expression systems and the surging popularity of precision medicine are the factors favoring the transient protein expression market progress. The plant-based expression systems for therapeutic protein production are expected to fuel the market in the coming years.
Transient Protein Expression Market Overview
Animal and plant cell-based transient protein expression systems have been in use for the last three decades. Significant advancements in proteomics in recent years have resulted in the availability of newer recombinant protein varieties. The practicality and reproducibility of transient protein expression in animal and plant cells encourage research and development activities to extend their applications in human cell lines. Many contract research and development organizations as well as biopharmaceutical companies, among others, have focused their efforts on incorporating transient protein expression into their production processes. This type of expression system allows them to use different genes to create recombinant proteins without relying on the development of stable cell lines.
The temporary protein expression process finds widespread application in the manufacturing of growth factors, cytokines, hormones, blood products, modified human proteins, and monoclonal antibodies. Moreover, the creation and use of effective bioprocessing techniques have become essential for the commercial synthesis of recombinant proteins with significant therapeutic value. Recent developments in the field of bioprocessing are being applied to provide efficient methods for generating recombinant proteins. Modern Quality by Design concepts, continuous upstream processing, continuous chromatography, integrated continuous bioprocessing, high-throughput devices for efficient bioprocess optimization, disposable systems, and process analytics technologies for higher yields of high-quality products are among the recent developments that propel the adoption of transient protein expression systems.
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Transient Protein Expression Market: Strategic Insights
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Transient Protein Expression Market Drivers and Opportunities
Surging Popularity of Precision Medicine Favors Market
With advancements in medical technologies, the use of molecular biology techniques has increased significantly in the R&D of various therapeutic or treatment modalities. Genomic transcriptomic information aids in the discovery of biomarkers that find applications in monitoring diseases and predicting their risks, serving as a key principle in different therapeutic modalities. The use of personalized or precision medicines has surged dramatically due to the availability of vast information on genetic variations existing among people. For instance, mRNA-mediated therapy is characterized by decreased immunogenicity, superior translation efficacy, enhanced stability, pharmaceutical safety, and transient protein expression, and only the modified mRNA is utilized for therapeutic application instead of incorporating the entire host genome.
Pharmaceutical and biotechnology industries have developed various innovative techniques to treat cancer and neurodegenerative diseases. Significant progress in research related to neurotrauma and neurodegenerative diseases owing to the capabilities unlocked by transient gene expression technique has resulted in the introduction of precision medicines for these conditions. Technological advancements in epigenetics, genetics, and proteomics also support the development of therapeutics for the treatment of various genetic and rare genetic diseases caused by single- and multiple-cell disorders.
Plant-Based Expression Systems for Therapeutic Protein Production in Emerging Countries to Create Market Opportunities
The use of microbial or mammalian cell-based expression systems has been a common practice in recombinant protein production processes; however, plant-based expression has been promoted as a cost-effective, scalable, safe, and sustainable alternative in recent years. Advancements in transient expression methods have resulted in a significantly shortened duration of protein synthesis and the improved yield of recombinant proteins in plant-based systems. A shift in consumer preference toward plant-based products compels pharmaceutical and biopharmaceutical companies to focus on plant-based synthesis of therapeutic proteins. The use of plants has excellent potential for improving yields of proteins that can be administered for the prevention or treatment of human and animal diseases. The use of therapeutic proteins is likely to surge in the healthcare sector in the coming years due to the ongoing restructuring of regulatory frameworks and growing awareness about transient protein expression in plants. Maximum scale‐up possibility, low growth costs, complex protein production ability, low contamination (especially involving human pathogens) risks, and optimized growth conditions are among the key advantages associated with carrying out transient protein expression in plants. Moreover, plants are considered safer compared to other expression systems as they do not produce endotoxins and cause less harm to humans. Thus, plant-based expression systems for therapeutic protein expression are emerging as vital opportunities for the transient protein expression market growth during the forecast period.
Transient Protein Expression Market Report Segmentation Analysis
Key segments that contributed to the derivation of the transient protein expression market analysis are product type, application, and end user.
- Based on product type, the transient protein expression market is segmented into instruments, reagents, expression vectors, and competent cells. The instruments segment held the largest market share in 2023.
- By application, the market is segmented into genomic research, gene therapy, bioproduction, cancer research, and drug development. The genomic research segment accounted for the largest share of the market in 2023.
- Based on end user, the transient protein expression market is segmented into pharmaceutical and biotechnology companies, academic and research institutes, and clinical research organizations. The pharmaceutical and biotechnology companies segment dominated the market in 2023.
Transient Protein Expression Market Share Analysis by Geography
The geographic scope of the transient protein expression market report is mainly divided into five regions: North America, Asia Pacific, Europe, the Middle East & Africa, and South & Central America. North America dominated the market in 2023. The North America transient protein expression market has been analyzed on the basis of the US, Canada, and Mexico. In terms of revenue, North America accounted for the largest market share in 2023. The US is the world's most important market for transient protein expression procedures and systems. The market growth in the country is attributed to extensive research and development activities in the biopharmaceuticals industry, a growing number of startups involved in protein expression, and the rising adoption of recombinant protein for therapeutic applications. In addition, the presence of various market leaders operating in the US contributes notably to the expansion of the transient protein expression market size. .
Transient Protein Expression Market Regional Insights
The regional trends and factors influencing the Transient Protein Expression Market throughout the forecast period have been thoroughly explained by the analysts at Insight Partners. This section also discusses Transient Protein Expression Market segments and geography across North America, Europe, Asia Pacific, Middle East and Africa, and South and Central America.
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Transient Protein Expression Market Report Scope
| Report Attribute | Details |
|---|---|
| Market size in 2023 | US$ 836.68 Million |
| Market Size by 2031 | US$ 1,320.38 Million |
| Global CAGR (2023 - 2031) | 5.9% |
| Historical Data | 2021-2022 |
| Forecast period | 2024-2031 |
| Segments Covered | By Product Type
|
| Regions and Countries Covered | North America
|
| Market leaders and key company profiles |
|
Transient Protein Expression Market Players Density: Understanding Its Impact on Business Dynamics
The Transient Protein Expression Market market is growing rapidly, driven by increasing end-user demand due to factors such as evolving consumer preferences, technological advancements, and greater awareness of the product's benefits. As demand rises, businesses are expanding their offerings, innovating to meet consumer needs, and capitalizing on emerging trends, which further fuels market growth.
Market players density refers to the distribution of firms or companies operating within a particular market or industry. It indicates how many competitors (market players) are present in a given market space relative to its size or total market value.
Major Companies operating in the Transient Protein Expression Market are:
- Thermo Fisher Scientific
- Promega Corporation
- Merck KGAA
- Takara Bio Inc
- Qiagen
- Bio-Rad Laboratories, Inc.
Disclaimer: The companies listed above are not ranked in any particular order.
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Transient Protein Expression Market News and Recent Developments
The transient protein expression market is evaluated by gathering qualitative and quantitative data post primary and secondary research, which includes important corporate publications, association data, and databases. A few of the developments in the transient protein expression market are listed below:
- Merck, a leading science and technology company, was granted its second patent for CRISPR-chrom technology. With this, the company became the only provider with a patent covering the fusion of chromatin-modulating peptides to CRISPR proteins, helping to clear chromatin out of the way, enhancing access to the genome. [Source: Merck, Company Website, February 2020]
Transient Protein Expression Market Report Coverage and Deliverables
The "Transient Protein Expression Market Size and Forecast (2021–2031)" report provides a detailed analysis of the market covering below areas:
- Transient protein expression market size and forecast at global, regional, and country levels for all the key market segments covered under the scope
- Transient protein expression market trends as well as market dynamics such as drivers, restraints, and key opportunities
- Detailed PEST/Porter's Five Forces and SWOT analysis
- Transient protein expression market analysis covering key market trends, global and regional framework, major players, regulations, and recent market developments
- Industry landscape and competition analysis covering market concentration, heat map analysis, prominent players, and recent developments for the transient protein expression market
- Detailed company profiles
- Historical Analysis (2 Years), Base Year, Forecast (7 Years) with CAGR
- PEST and SWOT Analysis
- Market Size Value / Volume - Global, Regional, Country
- Industry and Competitive Landscape
- Excel Dataset
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
This text is related
to segments covered.
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
This text is related
to country scope.
Frequently Asked Questions
North America dominated the market in 2023.
The integration of artificial intelligence (AI) and automation technologies is expected to be a key trend in the transient protein expression market in the future.
Thermo Fisher Scientific, Promega Corporation, Merck KGAA, Takara Bio Inc, Qiagen, Bio-Rad Laboratories, Inc., New England Biolabs, Genscript Biotech Corporation, Agilent, Lonza, Mirus Bio LLC, and MaxCyte Inc are among the key players operating in the market.
The transient protein expression market value is estimated to reach US$ 1,320.38 million in 2031.
The transient protein expression market is anticipated to record a CAGR of 5.9% during 2023–2031.
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The List of Companies - Transient Protein Expression Market
- Thermo Fisher Scientific
- Promega Corporation
- Merck KGAA
- Takara Bio Inc
- Qiagen
- Bio-Rad Laboratories, Inc.
- New England Biolabs
- Genscript Biotech Corporation
- Agilent, Lonza
- Mirus Bio LLC
- MaxCyte Inc
- DeRoyal Industries Inc
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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