Organoids Market Overview, Growth, Trends, Analysis, Research Report (2021-2031)

The organoids market size is projected to reach US$ 15.01 billion by 2031 from US$ 3.03 billion in 2023. The market is expected to register a CAGR of 22.3% in 2023–2031. The combination of organoids and organ-on-a-chip is likely to act as one of the key trends in the organoids market in the future.

Organoids Market Analysis

Factors contributing to the organoids market growth include the increasing demand for tumor modeling and biobanking, and a surging adoption of personalized drugs. However, the dearth of skilled professionals and stringent safety regulations hamper the market growth.

Organoids Market Overview

Organoids are microscopic and self-organized 3D structures derived in vitro from stem cells. They exhibit various structural and functional characteristics of their in vivo counterpart organs. This multipurpose technology has led to numerous new human cancer models. It is now possible to create indefinitely expanding organoids starting from the tumor tissue of individuals suffering from a variety of cancers. Alternatively, CRISPR-based gene modification allows the creation of cancer organoid models by introducing any combination of cancer gene modifications to normal organoids. Tumor organoids, when combined with immune cells and fibroblasts, generate a cancer microenvironment model that enables immune-oncology applications. Recent studies emphasize the significant role of organoids in personalized medicine approaches. Continuous advancements in organoid technology have enabled tumors and patient-centric 3D cultures of cells isolated from tumor biopsies. Organoids have been generated from breast, bladder, colon, prostate, pancreas, and liver cancer in humans over the past few decades. Studies involving these models help provide a clear overview of these malignancies. Tumoroid lines being introduced in vitro are opening new avenues for a range of downstream applications such as drug discovery and development and cancer research. Moreover, 3D-based cultures offer added advantages over conventional 2D cancer-derived cell lines.

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Organoids Market: Strategic Insights

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Organoids Market Drivers and Opportunities

Surging Adoption of Personalized Drugs Favors Organoids Market

Personalized medicine, also known as precision medicine, is a medical model that practices procedures or drugs that are tailored to the individual patient based on the anticipated response or disease risk. In a study published by the Personalized Medicine Coalition, the share of personalized medicines in the new FDA-approved molecular entities rose from 5% in 2005 to more than 25% in 2016. In addition, 37 new molecular entities (NMEs) were approved by the Center for Drug Evaluation and Research (CDER) of the Food and Drug Administration (FDA) in 2022. 12 of these NMEs, i.e.~34%, were personalized medicine. Moreover, biopharmaceutical companies have nearly doubled their R&D investments in personalized drugs, which is estimated to increase by 33% by 2027. Biopharmaceutical researchers also predict a 69% increase in the development of personalized medicines over the coming years. According to a report published in 2021 by the Personalized Medicine Coalition, the number of personalized medicines in the US market grew from 132 in 2016 to 286 in 2020.

Focus on Drug Discovery Activities to Create Opportunities for Organoids Market Growth

The increasing demand for new and advanced drugs is driving the overall pace of drug discovery and research. According to ClinicalTrials.gov, the total number of clinical trial studies in 2021 was estimated at 384,288. A recent survey by the HUB states that organoids can potentially make expensive drugs more cost-effective by identifying patients who are not likely to benefit from the drug and omitting them from clinical trials. An increasing number of clinical trials worldwide is expected to drive the demand for advanced medical technologies, including organoid models. Organoids in drug discovery are not limited to just cancer; they are also used in other disease studies, including cystic fibrosis, polycystic kidney disease, microcephaly, and gut and airway infections. For instance, organoids can summarize the properties of an organ, such as organ structure and function. They can also restore the original genetic and epigenetic state of a tissue or an organ, making them suitable for gene editing. Thus, the continued focus on drug discovery activities to tap the untapped areas of medicine offers more significant growth opportunities for the organoids market.

Organoids Market Report Segmentation Analysis

Key segments that contributed to the derivation of the organoids market analysis are type, application, source, type, and method.

• Based on type, the organoids market is classified into intestine, liver, stomach, pancreas, lung, brain, kidney, and others. The intestine segment held the largest share of the market in 2023, and it is further anticipated to register the highest CAGR during the forecast period.
• By application, the market is segmented into developmental biology, infectious disease pathology, regenerative medicine, drug toxicity and efficacy testing, drug discovery and personalized medicine, and others. The developmental biology disease segment held the largest share of the market in 2023; it is further anticipated to register the highest CAGR during 2023–2031.
• Based on source, the organoids market is divided into pluripotent stem cells and organ-specific adult stem cells. The microbial segment held a larger share of the market in 2023. The pluripotent stem cells segment is anticipated to register a higher CAGR during the forecast period.
• Based on offering, the organoids market is divided into instruments, consumables, and services. The consumables segment held the largest share of the market in 2023.
• Based on method, the organoids market is classified into micropatterned plates, ultralow attachment plates, hanging drop, microdroplet/emulsion, and others. The microbial segment held the largest share of the market in 2023. The hanging drop segment is anticipated to register the highest CAGR during the forecast period.

Organoids Market Share Analysis by Geography

The geographic scope of the organoids market report is mainly divided into five regions: North America, Asia Pacific, Europe, and the Middle East & Africa.

North America dominates the organoids market. Market players in the US are focusing on organic growth strategies to strengthen their foothold. Organoids have the potential to overcome several previous limitations in biomedical research aimed at gaining mechanistic insights into human development, producing accurate models of human disease, and generating patient-matched tissue sources for regenerative medicine. In 2023, researchers at the Wyss Institute at Harvard University and Duke University collaborated with Gameto to develop a human ovarian organoid that supports egg cell maturation and leads to new treatments for conditions such as infertility and ovarian cancer. The technology was licensed to Gameto in 2022 and is being used to develop therapeutics for diseases associated with the female reproductive system. Moreover, the US witnessed a rise in research activities on organoids. For instance, the Center for Stem Cell and Organoid Medicine (CuSTOM) at Cincinnati Children's Hospital is advancing personalized regenerative therapies using innovative stem cell technologies and organoids. The goal of the research is to engineer patient-specific, organoid-derived tissues for therapeutic transplantation. Thus, owing to the increasing research and development activities, rising need for tissue engineering and organ transplantation, and high adoption rate of organoids, the demand for organoids is expected to grow in the US during the forecast period.

Organoids Market Regional Insights

The regional trends and factors influencing the Organoids Market throughout the forecast period have been thoroughly explained by the analysts at Insight Partners. This section also discusses Organoids Market segments and geography across North America, Europe, Asia Pacific, Middle East and Africa, and South and Central America.

Organoids Market Market Report Scope

Market Players Density: Understanding Its Impact on Business Dynamics

The Organoids Market market is growing rapidly, driven by increasing end-user demand due to factors such as evolving consumer preferences, technological advancements, and greater awareness of the product's benefits. As demand rises, businesses are expanding their offerings, innovating to meet consumer needs, and capitalizing on emerging trends, which further fuels market growth.

Market players density refers to the distribution of firms or companies operating within a particular market or industry. It indicates how many competitors (market players) are present in a given market space relative to its size or total market value.

Major Companies operating in the Organoids Market are:

1. STEMCELL Technologies
2. Molecular Devices, LLC.
3. HUB Organoids B.V. (Hubrecht Organoid Technology)
4. DefiniGEN
5. Organoid Therapeutics
6. Thermo Fisher Scientific Inc.;

Disclaimer: The companies listed above are not ranked in any particular order.

Organoids Market News and Recent Developments

The organoids market is evaluated by gathering qualitative and quantitative data post primary and secondary research, which includes important corporate publications, association data, and databases. A few of the developments in the market are listed below:

• The government of Canada announced the opening of STEMCELL Technologies' new state-of-the-art facility in Burnaby, British Columbia. The investment allowed STEMCELL Technologies to build a new biomanufacturing facility meeting higher regulatory standards. This will support clinical trials for various medical treatments with the goal of finding cures for cancer and other serious diseases. (STEMCELL Technologies, Press Release, July 2024)

Organoids Market Report Coverage and Deliverables

The "Organoids Market Size and Forecast (2021–2031)" report provides a detailed analysis of the market covering below areas:

• Organoids market size and forecast at global, regional, and country levels for all the key market segments covered under the scope
• Organoids market trends as well as market dynamics such as drivers, restraints, and key opportunities
• Detailed PEST/Porter's Five Forces and SWOT analysis
• Organoids market analysis covering key market trends, global and regional framework, major players, regulations, and recent market developments.
• Industry landscape and competition analysis covering market concentration, heat map analysis, prominent players, and recent developments for the organoids market
• Detailed company profiles