Anticoagulant Reversal Drugs Market Forecast and Growth 2031

The Anticoagulant Reversal Drugs Market size is projected to reach US$ 2,442.87 million by 2031 from US$ 1306.40 million in 2023. The market is expected to register a CAGR of 10.08% in 2023–2031. Development and launch of innovative products are likely to remain key anticoagulant reversal drugs market trends.

Anticoagulant Reversal Drugs Market Analysis

In recent years, the use of anticoagulants has increased for preventing and treating various cardiovascular conditions such as pulmonary embolism (PE), deep vein thrombosis (DVT), atrial fibrillation (AF), mechanical heart valve thrombosis, and acute coronary syndromes. However, the widespread use of these treatments carries the risk of major and minor bleeding, leading to hospitalizations and emergency department visits. This risk can increase if patients are prescribed combination therapy consisting of an anticoagulant and antiplatelet or dual antiplatelet therapy. When used alone, warfarin and aspirin have the highest bleeding risk. Thus, anticoagulant reversal drugs are used to prevent bleeding. The rise in the prevalence of atrial fibrillation (AFib) and the increase in incidences of stroke are expected to favor the development of new treatments to improve speech.

Anticoagulant Reversal Drugs Market Overview

As highlighted by the Centers for Disease Control and Prevention (CDC), every year, more than 454,000 AFib-related hospitalizations occur in the US, resulting in about 158,000 deaths. Additionally, the risk of developing AFib increases with age, and high blood pressure, which also becomes more common with advancing age, is a factor in ~ 1 out of every 5 cases of AFib. The rising geriatric population is expected to bring an uptake in the demand for anticoagulant reversal drugs in the coming decade.

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Anticoagulant Reversal Drugs Market: Strategic Insights

Market Size Value in	US$ 922.55 Million in 2019
Market Size Value by	US$ 2,276.54 Million by 2027
Growth rate	CAGR of 12.6% from 2020-2027
Forecast Period	2020-2027
Base Year	2020

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Anticoagulant Reversal Drugs Market Drivers and Opportunities

Mounting Neurodegenerative Diseases and Speech Disorders to Favor Market

Anticoagulant reversal drugs are used in the management of hemorrhagic stroke to decrease ongoing bleeding and allow tissues to recover. There has been an increase in stroke prevalence in low- and middle-income countries. According to the Stroke Awareness Foundation, ~ 795,000 individuals suffer from a stroke each year in the US, accounting for over 140,000 deaths each year. Out of this number, ~ 40% of stroke-related deaths occur in males, while the remaining 60% occur in females. In an article published by Annals of Palliative Medicine (APM) in May 2021, a combination of 4-factor prothrombin complex concentrate, fresh frozen plasma, and vitamin K1 was administered in a patient under warfarin treatment who suffered from acute ischemic stroke (AIS). The report showed neurological improvement and successful reversal of coagulation regarding AIS patients with warfarin-related hypercoagulability. Therefore, propelling incidences of stroke are a major driver of anticoagulant reversal drugs market share.

Increasing Research Activities – An Opportunity in the Development of Novel Anticoagulant Reversal Drugs

Rapidly progressing research activities in drug development of novel therapeutics worldwide to counter the growing prevalence of cardiovascular diseases, such as atrial fibrillation, are driving the growth of the anticoagulant reversal drugs market. There is always a need for innovative therapeutic approaches in the treatment of various cardiovascular indications. For instance, the study titled ‘Evaluation of andexanet alfa and four‐factor prothrombin complex concentrate (4F‐PCC) for reversal of rivaroxaban‐ and apixaban‐associated intracranial hemorrhages,’ published in July 2020 in the Journal of Thrombosis and Haemostasis, was conducted in Massachusetts General Hospital, to investigate the efficacy of andexanet alfa in the treatment of intracranial hemorrhages (ICH). Thus, the increasing number of research activities is boosting drug discovery activities and offering lucrative opportunities for market growth across the industry.

Anticoagulant Reversal Drugs Market Report Segmentation Analysis

Key segments that contributed to the derivation of the anticoagulant reversal drugs market analysis are product and distribution channel.

• Based on product, the anticoagulant reversal drugs Market is divided into prothrombin complex concentrates, vitamin K, protamine, tranexamic acid, idarucizumab, and AndeXXa. The prothrombin complex concentrates segment held the largest share of the market in 2023.
• In terms of distribution channel, the anticoagulant reversal drugs market is segmented into hospital pharmacies, retail pharmacies, and others. The hospital pharmacies segment held the largest share of the market in 2023.

Anticoagulant Reversal Drugs Market Share Analysis by Geography

The geographic scope of the anticoagulant reversal drugs Market report is mainly divided into five regions: North America, Asia Pacific, Europe, Middle East & Africa, and South & Central America.

North America has dominated the anticoagulant reversal drugs market. In North America, the US is the largest market for anticoagulant reversal drugs. The growth of this market is primarily driven by the growing prevalence of cardiovascular diseases such as atrial fibrillation, developments by the market players, and the presence of major market players in the US will accelerate the growth of this market in this country. Also, strategic developments by the market players in the US are likely to favor the growth of the market. For instance, in June 2023, AstraZeneca proceeded with full regulatory filings for its Andexxa (andexanet alfa) in the US and EU, moving ahead from the current conditional approval. Andexxa is a treatment that can quickly reverse the anticoagulation effects of direct oral FXa inhibitors. Over 15 national and international guidelines across multiple disciplines support its use. AstraZeneca now proceeded with regulatory filings for full label approval in the US.

Anticoagulant Reversal Drugs Market Report Scope

Anticoagulant Reversal Drugs Market News and Recent Developments

The anticoagulant reversal drugs market is evaluated by gathering qualitative and quantitative data from primary and secondary research, which includes important corporate publications, association data, and databases. The following is a list of developments in the market for speech and language disorders and strategies:

• AstraZeneca Pharma India Ltd. announced that it received approval from the Central Drugs Standard Control Organisation (CDSCO) in India to import and market Andexanet Alfa. This treatment is effective in addressing life-threatening or refractory bleeding that comes with the use of Factor Xa (FXa) inhibitors. (Source: AstraZeneca Pharma, Press Release, 2024)
• Octapharma USA announced the approval of Balfaxar from the US Food and Drug Administration (FDA). Balfaxar is a non-activated four-factor prothrombin complex concentrate (4F-PCC) containing vitamin K-dependent factors: Factor II (prothrombin), Factor VII, Factor IX, and Factor X, and antithrombotic Proteins C and S. It can be used to urgently reverse acquired coagulation factor deficiency induced by vitamin K antagonist (VKA) therapy in adult patients who require urgent surgery or invasive procedures. Balfaxar helps restore blood coagulation by replenishing the levels of deficient clotting factors due to warfarin therapy. (Source: Octapharma USA, Inc, Press Release, 2023)

Anticoagulant Reversal Drugs Market Report Coverage and Deliverables

The “Anticoagulant Reversal Drugs Market Size and Forecast (2021–2031)” report provides a detailed analysis of the market covering below areas:

• Market size and forecast at global, regional, and country levels for all the key market segments covered under the scope
• Market dynamics such as drivers, restraints, and key opportunities
• Key future trends
• Detailed PEST/Porter’s Five Forces and SWOT analysis
• Global and regional market analysis covering key market trends, major players, regulations, and recent market developments
• Industry landscape and competition analysis covering market concentration, heat map analysis, prominent players, and recent developments
• Detailed company profiles