Botulinum Toxin Market Overview, Trends, Size by 2031

Botulinum Toxin Market Size and Forecast (2021 - 2031), Global and Regional Share, Trend, and Growth Opportunity Analysis Report Coverage: By Product (Botulinum Toxin A and Botulinum Toxin B), Application (Medical and Aesthetic), End User (Specialty and Dermatology Clinics, Hospitals and Clinics, and Others), and Geography (North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America)

  • Report Code : TIPRE00027431
  • Category : Pharmaceuticals
  • Status : Published
  • No. of Pages : 381
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Botulinum Toxin Market Overview, Trends, Size by 2031

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The botulinum toxin market is projected to grow from US$ 7.38 billion in 2023 to US$ 19.03 billion by 2031, recording a CAGR of 12.6% during 2023–2031. The report includes growth prospects owing to the current botulinum toxin market trends and their foreseeable impact during the forecast period.

Botulinum toxins are neurotoxins produced by bacteria named Clostridium botulinum. After the toxin is injected into a muscle, it blocks nerve signals to the muscle, thereby blocking its contraction and resulting in a reduction in unwanted facial lines or features. Botulinum toxin injections such as Botox and Dysport improve the appearance by relaxing the muscles that cause wrinkles. These injections also treat migraines, hyperhidrosis, overactive bladder, and eye problems. The botulinum toxin market size is likely to surge by 2031 owing to significant growth opportunities presented by developing countries.

Growth Drivers:

Increasing Use of Botulinum Toxin for Enhancing Facial Aesthetics Drives Botulinum Toxin Market

Cosmetic surgery and injectable botulinum toxin are among the most popular noninvasive rejuvenation procedures. According to the ISAPS, in 2020, the botulinum toxin treatment was the leading noninvasive cosmetic procedure performed worldwide. Moreover, botulinum toxin type A-based (BoNTA) facial cosmetic treatments are performed to improve the aesthetics of the upper and lower face. In the last decade, a facial rejuvenation procedure gained significant popularity over different types of traditional surgeries. According to the ISAPS, ~7.3 million botulinum toxin procedures were performed globally in 2020. Moreover, a total of 2.5 million minimally invasive cosmetic procedures involving botulinum toxin were performed in the US in 2020. Thus, an upsurge in the adoption of botulinum toxin in facial aesthetic procedures for both men and women from all age groups is driving the botulinum toxin market growth.

Nonsurgical Procedures, by Country, 2021

Nonsurgical Procedures

Worldwide

US

Brazil

Japan

Mexico

Italy

Germany

Turkey

Argentina

India

Greece

Botulinum Toxin

7,312,616

2,520,000

542,520

458,749

266,928

129,720

306,296

229,346

158,900

99,384

76,626

Source: The International Society of Aesthetic Plastic Surgery (ISAPS), 2021

Although botulinum treatment is approved worldwide to treat eyelid and throat spasms, reduce facial wrinkles, and control excessive sweating, the toxin may cause serious side effects that can be life-threatening. Common side effects of botulinum toxin treatments are mentioned below.

  • Patients face problems in speaking, swallowing, or breathing due to the weakening of associated muscles. These side effects can be severe and result in mortality.
  • Spread of botulinum toxin to body areas other than the injection site causes severe symptoms. These ill effects include the loss of strength and muscle weakness, blurred vision, double vision, drooping eyelids, trouble saying words clearly, hoarseness or change or loss of voice, loss of bladder control, trouble swallowing, and difficulty breathing.
  • Other side-effects of botulinum toxin include upper respiratory tract infection. Children receiving botulinum treatment for urinary incontinence may experience urinary tract infections and bacteria in the urine. Other side effects in adults treated for urinary incontinence include painful urination, apart from urinary tract infections.

Botox has a boxed warning. A boxed warning is an official alert from the Food and Drug Administration (FDA) regarding potentially harmful side effects of a medication. Spreading of Botox outside of the injection site may result in symptoms identical to those of botulism. Further, headache or flu-like symptoms, crooked smile, and dry eyes are the other major side effects of botulinum toxin. Such harmful side effects limit the adoption of botulinum toxin treatment, thereby hampering the botulinum toxin market growth.

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Botulinum Toxin Market: Strategic Insights

botulinum-toxin-market
Market Size Value inUS$ 5,307.71 Million in 2021
Market Size Value byUS$ 8,977.62 Million by 2028
Growth rateCAGR of 7.8% from 2021 to 2028
Forecast Period2021-2028
Base Year2021
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Report Segmentation and Scope:

The botulinum toxin market analysis is performed by considering the following segments: product, application, and end user.

Segmental Analysis:

By product, the botulinum toxin market is bifurcated into botulinum toxin A and botulinum toxin B. The botulinum toxin A segment held a larger botulinum toxin market share in 2023. It is anticipated to register a higher CAGR of 12.7% during 2023–2031. Botulinum toxin type A is a purified form that has a wide range of applications and a favorable safety profile. It is used to block the release of acetylcholine in the treatment of chronic sialorrhea, spasticity, and dystonia, as well as in various cosmetic applications.

By application, the botulinum toxin market is bifurcated into medical and aesthetic. The medical segment held a larger market share in 2023, and it is anticipated to register a higher CAGR of 13.3% during 2023–2031. The market for the medical segment is further categorized into chronic migraine, muscle spasm, overreactive bladder, hyperhidrosis, and others. Also, the market for the aesthetic segment is subsegmented into frown lines/glabellar, forehead lines, crow’s feet, square jaw/masseter, and others. Botulinum toxin is a neurotoxin used to treat and manage various medical conditions, including chronic migraine, spastic disorders, cervical dystonia, and detrusor hyperactivity. Medical applications of botulinum toxin include chronic migraine, muscle spasms, overreactive bladder, and hyperhidrosis.

The botulinum toxin market, by end user, is segmented into specialty and dermatology clinics, hospitals and clinics, and others. The specialty and dermatology clinics segment held the largest market share in 2023. It is anticipated to register the highest CAGR of 13.4% during the forecast period.

Regional Analysis:

The scope of the botulinum toxin market report includes North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America. In 2023, North America accounted for the largest botulinum toxin market share. Market growth in this region is driven by increasing numbers of nonsurgical or minimally invasive cosmetic procedures performed in the abovementioned countries. Reduction of facial wrinkles with botulinum toxin injections is the most performed cosmetic procedure in the US. It is one of the most common entry-level procedures for clinicians willing to incorporate aesthetic treatments into their practice. According to the International Society of Aesthetic Plastic Surgery (ISAPS), nearly 2.5 million botulinum toxin procedures were performed in the US in 2021. The treatment of frown lines and crow's feet by the FDA-approved botulinum toxin treatment methods for cosmetic indications and horizontal forehead wrinkles provide predictable results, alongside exhibiting fewer side effects and high patient satisfaction. BOTOX Cosmetic/Vistabel by Allergan, Dysport/Azzalure by Galderma and Ipsen, Xeomin/Bocouture by Merz, and Jeuveau by Evolus (manufactured only by Daewoong for the US) are among the commercially available botulinum toxin products in the country. The US FDA has approved BOTOX Cosmetic for people from the age range of 18–65.

Europe occupies a significant position in the global botulinum toxin market, and it is expected to record a strong growth rate during the forecast period. The market growth in the region is mainly attributed to product developments by botulinum toxin companies and an upsurge in the awareness of modern beauty standards among people from all age groups in European countries such as Germany, the UK, France, and Italy. In addition, advancements in healthcare systems are likely to propel the demand for botulinum toxin across the region in the coming years.

Botulinum Toxin Market Report Scope

Competitive Landscape and Key Companies:

The botulinum toxin market forecast can help stakeholders in this marketplace plan their growth strategies. AbbVie Inc., Merz Pharma, Medytox, Ipsen Pharma, Galderma, Revance Therapeutics Inc., Lanzhou Institute of Biological Products Co Ltd, Evolus Inc, Hugel Inc, and Aquavit are among the prominent companies profiled in the botulinum toxin market report. These companies focus on developing new technologies, upgrading existing products, and expanding their geographic presence to meet the growing consumer demand worldwide. As per company press releases, below are a few recent developments:

  • In January 2024, Medytox, Inc. announced the formation of Luvantas, Inc. as its wholly owned North American subsidiary. Luvantas is a new medical aesthetics company committed to bringing innovative solutions to the North American market. It is working with Medytox to seek approval for its upcoming NivobotulinumtoxinA to introduce it into the US and Canada.
  • In March 2024, Hugel, a medical aesthetics company, received US FDA approval for Letybo injection (letibotulinumtoxinA-wlbg) for the treatment of Glabellar Lines.
  • In October 2022, Hugel resubmitted the Biologics License Application (BLA) to the US FDA for its botulinum toxin called Botulax for the treatment of glabellar lines. Hugel received a Complete Response Letter (CRL) from the US FDA in March 2022 after submitting the BLA for Botulax (50 and 100 units) to advance into the US market. The company sent supplemental documents and data based on requests set out in the CRL and resubmitted the BLA to the US FDA. After the approval, Hugel entered into the US market in the first half of 2023.
  • In February 2022, Merz Therapeutics invested up to US$ 3 million to expand its strategic partnership with Vensica Therapeutics, Israel. This investment followed the strategic license and collaboration agreement signed in 2021. Merz thus executed its contractual agreement to participate in Vensica’s Series C financing round and invest in the start-up.
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

Product Type, Application, and End User

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

Argentina, Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Saudi Arabia, South Africa, South Korea, Spain, United Arab Emirates, United Kingdom, United States

Frequently Asked Questions


Which product segment is dominating the botulinum toxin market?

The botulinum toxin market, based on product, is bifurcated into botulinum toxin A and botulinum toxin B. The botulinum toxin A segment held a larger market share in 2023, and it is anticipated to register a higher CAGR during 2023–2031.

Which country is dominated the botulinum toxin market?

US holds the largest market share in botulinum toxin market. Facial wrinkle reduction with botulinum toxin injections is the most performed cosmetic procedure in the US. It is one of the most common entry-level procedures for clinicians willing to incorporate aesthetic treatments into their practice. According to the ISAPS, nearly 2.5 million botulinum toxin procedures were performed in the US in 2021. BOTOX Cosmetic/Vistabel by Allergan, Dysport/Azzalure by Galderma and Ipsen, Xeomin/Bocouture by Merz, and Jeuveau by Evolus (manufactured only by Daewoong for the US) are among the commercially available botulinum toxin products in the country. The US FDA has approved BOTOX Cosmetic for people from the age group of 18–65.

Which end user segment is dominating the botulinum toxin market?

The botulinum toxin market by end user, is categorized into specialty and dermatology clinics, hospitals and clinics, and others. The specialty and dermatology clinics segment held the largest market share in 2023.

Which application segment is dominating the botulinum toxin market?

The botulinum toxin market by application is bifurcated into medical and aesthetic. The medical segment held the largest botulinum toxin market share in 2023 and is anticipated to register the highest CAGR of 13.3% during 2023–2031.

Who are the major players in the botulinum toxin market?

The botulinum toxin market majorly consists of the players such as AbbVie Inc., Merz Pharma, Medytox, Ipsen Pharma, Galderma, Revance Therapeutics Inc., Lanzhou Institute of Biological Products Co Ltd, Evolus Inc, Hugel Inc, and Aquavit.

What is botulinum toxin?

Botulinum toxins are neurotoxins produced by bacteria named Clostridium botulinum. After the toxin is injected into a muscle, it blocks nerve signals to the muscle, thereby blocking its contraction and resulting in a reduction in unwanted facial lines or features. Botulinum toxin injections such as Botox and Dysport improve the appearance by relaxing the muscles that cause wrinkles. These injections also treat migraines, hyperhidrosis, overactive bladder, and eye problems..

What are the driving factors for the botulinum toxin market across the globe?

The factors that are driving growth of the market are the rising popularity of non-invasive aesthetics procedures and increasing use of botulinum toxin for enhancing facial aesthetics.

1. Introduction

1.1 Scope of the Study

1.2 Market Definition, Assumptions and Limitations

1.3 Market Segmentation

2. Executive Summary

2.1 Key Insights

2.2 Market Attractiveness Analysis

3. Research Methodology

4. Botulinum Toxin Market Landscape

4.1 Overview

4.2 PEST Analysis

4.3 Ecosystem Analysis

4.3.1 List of Vendors in the Value Chain

5. Botulinum Toxin Market - Key Market Dynamics

5.1 Key Market Drivers

5.2 Key Market Restraints

5.3 Key Market Opportunities

5.4 Future Trends

5.5 Impact Analysis of Drivers and Restraints

6. Botulinum Toxin Market - Global Market Analysis

6.1 Botulinum Toxin - Global Market Overview

6.2 Botulinum Toxin - Global Market and Forecast to 2031

7. Botulinum Toxin Market – Revenue Analysis (USD Million) – By Product, 2021-2031

7.1 Overview

7.2 Botulinum Toxin A

7.3 Botulinum Toxin B

8. Botulinum Toxin Market – Revenue Analysis (USD Million) – By Application, 2021-2031

8.1 Overview

8.2 Medical

8.2.1 Chronic Migraine

8.2.2 Muscle Spasm

8.2.3 Over Reactive Bladder

8.2.4 Hyperhidrosis

8.2.5 Others

8.3 Aesthetic

8.3.1 Crow’s Feet

8.3.2 Forehead Lines

8.3.3 Frown Lines/ Glabellar

8.3.4 Square Jaw/ Masseter

8.3.5 Others

9. Botulinum Toxin Market – Revenue Analysis (USD Million) – By End User, 2021-2031

9.1 Overview

9.2 Specialty and Dermatology Clinics

9.3 Hospitals and Clinics

9.4 Others

10. Botulinum Toxin Market - Revenue Analysis (USD Million), 2021-2031 – Geographical Analysis

10.1 North America

10.1.1 North America Botulinum Toxin Market Overview

10.1.2 North America Botulinum Toxin Market Revenue and Forecasts to 2031

10.1.3 North America Botulinum Toxin Market Revenue and Forecasts and Analysis - By Product

10.1.4 North America Botulinum Toxin Market Revenue and Forecasts and Analysis - By Application

10.1.5 North America Botulinum Toxin Market Revenue and Forecasts and Analysis - By End User

10.1.6 North America Botulinum Toxin Market Revenue and Forecasts and Analysis - By Countries

10.1.6.1 United States Botulinum Toxin Market

10.1.6.1.1 United States Botulinum Toxin Market, by Product

10.1.6.1.2 United States Botulinum Toxin Market, by Application

10.1.6.1.3 United States Botulinum Toxin Market, by End User

10.1.6.2 Canada Botulinum Toxin Market

10.1.6.2.1 Canada Botulinum Toxin Market, by Product

10.1.6.2.2 Canada Botulinum Toxin Market, by Application

10.1.6.2.3 Canada Botulinum Toxin Market, by End User

10.1.6.3 Mexico Botulinum Toxin Market

10.1.6.3.1 Mexico Botulinum Toxin Market, by Product

10.1.6.3.2 Mexico Botulinum Toxin Market, by Application

10.1.6.3.3 Mexico Botulinum Toxin Market, by End User

Note - Similar analysis would be provided for below mentioned regions/countries

10.2 Europe

10.2.1 Germany

10.2.2 France

10.2.3 Italy

10.2.4 Spain

10.2.5 United Kingdom

10.2.6 Rest of Europe

10.3 Asia-Pacific

10.3.1 Australia

10.3.2 China

10.3.3 India

10.3.4 Japan

10.3.5 South Korea

10.3.6 Rest of Asia-Pacific

10.4 Middle East and Africa

10.4.1 South Africa

10.4.2 Saudi Arabia

10.4.3 U.A.E

10.4.4 Rest of Middle East and Africa

10.5 South and Central America

10.5.1 Brazil

10.5.2 Argentina

10.5.3 Rest of South and Central America

11. Industry Landscape

11.1 Mergers and Acquisitions

11.2 Agreements, Collaborations, Joint Ventures

11.3 New Product Launches

11.4 Expansions and Other Strategic Developments

12. Competitive Landscape

12.1 Heat Map Analysis by Key Players

12.2 Company Positioning and Concentration

13. Botulinum Toxin Market - Key Company Profiles

13.1 AbbVie Inc.

13.1.1 Key Facts

13.1.2 Business Description

13.1.3 Products and Services

13.1.4 Financial Overview

13.1.5 SWOT Analysis

13.1.6 Key Developments

Note - Similar information would be provided for below list of companies

13.2 Merz Pharma

13.3 Aquavit Holdings

13.4 Evolus, Inc

13.5 Ipsen Pharma

13.6 Medytox Inc.

13.7 GALDERMA

13.8 HUGEL, Inc.

13.9 Revance Therapeutics Inc

13.10 Lanzhou Institute of Biological Products Co Ltd

14. Appendix

14.1 Glossary

14.2 About The Insight Partners

14.3 Market Intelligence Cloud

The List of Companies - Botulinum Toxin Market 

  1. F. Hoffmann-La Roche Ltd
  2. Becton Dickinson and Co 
  3. ARKRAY Inc 
  4. Sysmex Partec GmbH 
  5. Fujirebio Europe NV
  6. bioMerieux SA
  7. Cepheid 
  8. Meril Life Sciences Pvt Ltd
  9. QIAGEN NV
  10. OraSure Technologies Inc

The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published many reports and advised several clients across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organizations are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in the last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/Sales Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • 3.1 Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • 3.2 Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • 3.3 Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • 3.4 Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.

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