Physiological Saline Market Size Report | Share Forecasts to 2030

[Research Report] The physiological saline market size is expected to grow from US$ 5,522.17 million in 2022 to US$ 9,057.04 million by 2030. The market is estimated to register a CAGR of 6.4% from 2022 to 2030. 

Analyst’s Viewpoint

The physiological saline market analysis explains growth drivers such as the rising prevalence of serious illnesses and fluid electrolyte disorders, and surging demand for fluid electrolytes in the elderly population. Further, large-scale saline solution requirements in hospital settings are expected to emerge as new trends in the market during 2022–2030. The physiological saline market, by type, is segmented into normal saline, hypertonic saline, hypotonic saline, and balanced saline. The normal saline segment held the largest market share in 2022. However, hypertonic saline segment is anticipated to register the highest CAGR during 2022–2030. The physiological saline market, by packaging type, is segmented into flexible bags, plastic bottles, and glass bottles. The plastic bottles segment held the largest market share in 2022. The flexible bag segment is anticipated to register the highest CAGR during 2022–2030. The physiological saline market, by application, is segmented as intravenous, ophthalmology, wound care, endoscopy, skin abrasion, and others. The intravenous segment held the largest market share in 2022, and the same segment is anticipated to register the highest CAGR during 2022–2030. The physiological saline market, by route of administration, is categorized into intravenous and topical. The intravenous segment held a larger market share in 2022, and the same segment is anticipated to register a higher CAGR during 2022–2030. The physiological saline market, by end user, is segmented into hospitals, specialty clinics, ambulatory surgical centers, home care, and others. The hospitals segment held the largest market share in 2022. The specialty clinics segment is anticipated to register the highest CAGR during 2022–2030.

A physiological saline solution is composed of salt solutions that are isotonic and have the same pH. An example of a physiological saline solution is Ringer's solution, composed of a mixture of sodium chloride (NaCl), sodium bicarbonate, and potassium chloride solution. A physician recommends the administration of a physiological solution to treat cases of dehydration, fluid imbalance, and many other similar clinical abnormalities.

Market Insights

Rising Prevalence of Serious Illnesses and Fluid Electrolyte Disorders Propels Physiological Saline Market

People with serious illnesses often experience a profound loss of independence, time, and capabilities. The emotional, physical, and financial toll can be life-altering for people suffering from distress in addition to physical symptoms with specific mental conditions. According to statistics revealed by the Commonwealth Fund report, 62% of people with serious illness experience anxiousness, confusion, or helplessness. 48% have emotional or psychological problems caused by the condition, and 32% report feeling left out, lacking companionship, and isolated from others. A report by the National Health Council reveals that incurable and ongoing chronic diseases affect nearly 133 million Americans, which represents more than 40% of the total population of the country. Among these, almost 50% of all adults and nearly 8% of children aged 5–17 have a chronic condition. The National Health Council’s report also mentions that the increasing cases of incurable chronic diseases among Americans result in ~75% of the healthcare costs.

Serious illnesses result in an imbalance in body fluids, such as low levels of potassium, magnesium, calcium, and sodium in the body. Improper levels of body fluids negatively impact the body's function, muscle strength, and heart rhythm, which is associated with disorders of kidneys or endocrine glands. For example, edema occurs when the body retains excessive fluid levels, resulting in swelling and pain in the face, arms, legs, hands, and feet of patients. Further, losing more body fluids than consumed quantities results in dehydration, which eventually leads to symptoms such as thirst, weakness, lightheadedness, fainting, and decreased urine output among patients. Therefore, chronic illnesses may result in body fluid imbalance in the patient's body, which propels the demand for physiological saline that is administered as a part of their treatment. Thus, the rising prevalence of serious illnesses and fluid electrolyte disorders bolsters the physiological saline market growth.

Future Trend

Large-Scale Saline Solution Requirements in Hospital Settings

According to a report published by the Royal Society of Chemistry, using saline solution for washing red blood cells (RBCs) and treating critically ill patients is a common practice in hospital settings. Clinical research groups have reviewed the safety of using physiological saline (0.9% NaCl) in different clinical settings and suggested that the use of saline solution is one of the safest techniques in hospital settings. For example, in transfusion medicine, saline solution is used for washing cells and salvaging procedures in cases of apheresis and the resuscitation of patients with blood or fluid loss. Washing of RBCs requires 1–2 L of sterile saline solution. In the apheresis procedure, saline solution is used in therapeutic plasma exchange procedures and intra-operative cell salvaging to wash RBCs. Therefore, the multifaceted application of physiological saline on large scales in hospital settings is likely to emerge as a new trend in the physiological saline market.

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Physiological Saline Market: Strategic Insights

Market Size Value in	US$ 5,522.17 million in 2022
Market Size Value by	US$ 9,057.04 million by 2030
Growth rate	CAGR of 6.4% from 2022 to 2030
Forecast Period	2022-2030
Base Year	2022

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Report Segmentation and Scope

Type-Based Insights

The physiological saline market, by type, is segmented into normal saline, hypertonic saline, hypotonic saline, and balanced saline. The normal saline segment held the largest market share in 2022; hypertonic saline segment is anticipated to register the highest CAGR during 2022–2030. Normal saline (NS) comprises a sterile salt solution used for short-term fluid replacement, as it helps restore electrolyte/salt levels in the body. It is a 0.9% sodium chloride solution intended to treat dehydration and electrolyte disturbances among people. NS is a cornerstone of intravenous solutions that are used commonly in clinical settings. It is suitable for both pediatric and adult patient populations. Primary indications for the use of NS solutions approved by the US Food and Drug Administration (FDA) are mentioned below:

• Extracellular fluid replacement to treat dehydration, hypovolemia, hemorrhage, sepsis, etc.
•   Treatment of metabolic alkalosis in the presence of fluid loss
•   Mild sodium depletion

Further, NS can only be administered through intravenous access, and the management of normal saline requires evaluation of the patient's health status. Pharmacists need to monitor the implementation of IV fluids while installing in the hospitals.

Packaging Type-Based Insights

The physiological saline market, by packaging type, is segmented into flexible bags, plastic bottles, and glass bottles. The plastic bottles segment held the largest market share in 2022. The flexible bags segment is anticipated to register the highest CAGR during 2022–2030. Sodium chloride (NaCl) USP solutions for injections are sterile and nonpyrogenic. They are parenteral solutions that contain various concentrations of NaCl in water for injection (WFI) intended for intravenous (IV) administration. Further, the flexible container is fabricated from a specially formulated polyvinyl chloride. However, solutions stored in plastic containers might trigger the leaching of certain chemical components from the plastic in tiny amounts. Nonetheless, the safety of plastic container materials can be tested effectively through biological evaluation methods. The plastic bottles segment is expected to account for the smallest share of the physiological saline market during the forecast period.

Application-Based Insights

The physiological saline market, by application, is segmented as intravenous, ophthalmology, wound care, endoscopy, skin abrasion, and others. The intravenous segment held the largest market share in 2022. It is further anticipated to register the highest CAGR during 2022–2030. Intravenous (IV) saline solutions are formulated for the prevention or treatment of dehydration. IV saline is prescribed by physicians for people who are injured, sick, dehydrated, or undergoing surgery, irrespective of their age. Saline IV bags provide a rapid and targeted solution to replenish fluids and relieve symptoms. Furthermore, a combination of sterile water and sodium chloride, or salt and normal saline IVs, helps restore fluid balance and hydrate tissues among patients. IV saline is commonly administered directly into patients’ bloodstreams when they require hydration. It is considered a suitable option for people with allergies or sensitivities to specific medications.

Various companies are offering innovative IV saline products; for example, Fresenius Kabi USA offers "freeflex" and "freeflex+ IV bags." These products also provide leak prevention, sterility protection, and needle-stick prevention.

Route of Administration-Based Insights

The physiological saline market, by route of administration, is categorized into intravenous and topical. The intravenous segment held the largest market share in 2022. The market for this segment is anticipated to register the highest CAGR during 2022–2030. IV saline solutions are specially formulated liquids that are injected into a vein to prevent and treat dehydration. Also, these IV fluids are utilized among people of all ages suffering from sickness, injury, dehydration, etc. The IV saline solution is administered via a simple and safe procedure that is associated with a low risk of complications. Also, fluid resuscitation is a vital component for the management of acutely ill patients, and normal saline is considered to be the most widely used IV fluid for seriously ill or injured patients. Being a common, simple, and safe procedure, patients administered via the IV route may feel relief in a short span.

Physiological Saline Market Report Scope

Regional Analysis

Asia Pacific is expected to register the highest CAGR in the global physiological saline market during 2022–2030. The market in Asia Pacific is segmented into China, India, Japan, South Korea, Australia, and the Rest of Asia Pacific. China holds the largest share of the physiological saline market in Asia Pacific. The physiological saline market growth in China during 2020–2030 is ascribed to the rising chronic disease incidences. According to the National Health Commission of the People's Republic of China, more than 300 million patients have been diagnosed with chronic diseases, accounting for 86.6% of the total chronic disease deaths. China also reports the second-highest number of tuberculosis (TB) cases. In 2020, nearly 842,000 people were diagnosed with TB in China, as per the statistics revealed by the Centers for Disease Control and Prevention (CDC). Likewise, chronic diseases among the patients have resulted in accelerated demand for physiological saline. The UCLA Health 2023 report reveals that the medical community understood the role of dietary science and nutrition in chronic disease progression. Therefore, simple strategies such as reducing sodium intake as well as minimizing added refined sugar and saturated fat consumption can help prevent diet-associated illnesses and promote overall wellness. This nutritional content is supplied through a physiological saline solution comprising salts (sodium and potassium), sugars (carbohydrates and glucose), plant-based and animal-source diets, water intake for wellness, coffee and tea, fruit juice or soda, and so on.

The report profiles leading players operating in the physiological saline market. These include Fresenius Kabi AG, Merck KGaA, AdipoGen Life Sciences Inc, Enzo Life Sciences Inc, ICU Medical Inc, Grifols SA, Geno Technology Inc, B Braun Medical Inc, Pfizer Inc, and Ward's Science.