Biosimulation Market Key Players Analysis 2031
【研究报告】2022年生物模拟市场规模为32.2亿美元，预计生物模拟市场规模将达到美元 到 2030 年将达到 100.9 亿。预计 2022-2030 年复合年增长率为 15.3%。
市场洞察和分析师观点：
生物模拟，也称为建模和模拟，利用生物过程的计算机模拟来预测生物系统在研究和研究过程中的行为;发展活动。这些是复制生物系统、过程和动力学的数学模拟。药物开发研发活动的增加、技术先进产品用于药物发现和药物开发以及人工智能和机器学习用于药物开发的使用正在推动生物刺激市场的增长。此外，制药和生物技术公司引入生物刺激正在推动生物模拟市场的增长。
增长动力：
制药行业是全球研发最密集的行业之一。随着制药公司热衷于确保研发实现其预期目标，药品的价值变得越来越重要。在过去十年中，每年批准的新药数量也有所增加。美国食品药品监督管理局 (FDA) 到 2022 年每年批准 37 种新药。我们正在努力提高满足患者需求的有效性和效率。以研究为基础的行业将约 15-20% 的收入分配给研发活动，每年研发投资超过 500 亿美元。在全球范围内，美国是研发投资的领先国家，在过去十年中生产了全球一半以上的新分子。研发是制药公司业务的重要组成部分，因为它使制药公司能够为具有巨大医疗和商业潜力的各种治疗应用开发新分子。
主要药企研发投入
公司 | 2021年研发投入（十亿美元） | 研发投入2022 年（十亿美元） |
武田制药有限公司 | 4.2 | 4.6 |
辉瑞公司 | 10.3 | < p>11.4 |
Grifols SA | 404.57 | 427.05 |
注意：显示货币时会考虑当前汇率。
< span>资料来源：年度报告和 Insight Partners 分析
研发支出用于发现、检验和生产新产品，以及前期准备付款，改善现有成果，并在推出前证明产品功效和法规合规性。研发投资根据临床试验的需要和要求而有所不同。成本包括材料、使用的用品和工资，以及开发质量控制的成本。
临床试验有助于确定新的治疗或预防形式，例如新的药物、饮食或医疗器械是安全有效的。试验主要在药物开发过程中进行。根据美国国家医学图书馆 (NLM) 提供的数据，2021 年在 NLM (ClinicalTrials.gov) 注册了约 52,000 项新研究，到 2023 年增加到约 58,000 项。2023 年 1 月，NLM 报告了 38,837 项正在进行的临床试验在美国和全球范围内进行了 105,172 项活跃试验。据欧洲药品管理局统计，欧盟（EU）每年授权约4,000项临床试验，其中约60%的临床试验与制药行业相关。
<此外，临床试验的程序越来越复杂，因此对研究组织中发生的操作的正确执行和监督变得至关重要。为了避免因执行不当而出现错误，研究型组织正在外包临床试验来开发其产品。使用模拟软件开发药物的临床试验数量不断增加，以及对药品研发活动的投资不断增加，正在推动市场的增长。
战略见解
报告细分和范围：
“全球生物模拟市场”细分是根据产品类型、应用、最终用户和地理位置进行的。根据产品类型，生物模拟市场分为软件和服务。服务进一步细分为内部服务和合同服务。根据应用，生物模拟市场分为临床前和临床药物开发、药物发现等。根据最终用户，生物模拟市场分为制药和生物模拟市场。生物技术公司、研究机构、合同研究组织等。基于地理位置的生物模拟市场分为北美（美国、加拿大和墨西哥）、欧洲（德国、法国、意大利、英国、俄罗斯和欧洲其他地区）、亚太地区（澳大利亚、中国、日本、印度、韩国、亚太地区其他地区）、中东和美国非洲（南非、沙特阿拉伯、阿联酋以及中东和非洲其他地区）以及南美和非洲中美洲（巴西、阿根廷以及南美洲和中美洲其他地区）。
< u>细分分析：
根据产品类型，生物模拟市场分为软件和服务。服务进一步细分为内部服务和合同服务。 2022年，按产品类型划分，软件领域在生物模拟市场中占据最大的市场份额。然而，预计服务领域在预测期内将以最高的复合年增长率增长。生物模拟软件使研究人员能够建模和模拟复杂的生物系统，有助于预测药物行为、优化治疗策略以及减少与传统实验相关的成本和时间。生物模拟解决方案促进协作、数据集成和法规遵从性，使科学家能够做出明智的决策，加速药物开发并改善患者的治疗结果。
按产品类型划分的生物模拟市场&ndash ; 2022年和2031年
根据最终用户，生物模拟市场分为制药和生物模拟市场。生物技术公司、研究机构、合同研究组织等。 2022年，医药行业生物技术公司部门占据了最大的生物模拟市场份额。然而，合同研究组织部门预计在预测期内将以最高的复合年增长率增长。临床研究组织 (CRO) 通过使用高质量设施和深厚的主题专业知识提供的服务，协助成功实施临床试验。 CRO 已开始通过其高效且具有成本效益的运营使试验申办者受益，成为临床试验行业的支柱。根据赛默飞世尔科技发布的博客，到 2022 年，约四分之三的临床试验由 CRO 进行，以确保药物开发商的临床计划，提高时间和成本效率，提供丰富的专业知识，并提供定制的、高质量的数据。合同研究趋势的广泛采用不仅被制药公司所见证，也被政府组织所见证。在特定时间内完成试验的严格规定也导致政府组织将研发活动外包。此外，政府增加对医疗保健行业的投资以开发慢性病药物预计也将推动对生物模拟的需求。因此，开发具有成本效益的解决方案和减少药物开发过程中 CRO 的错误正在推动生物模拟市场的增长。
区域分析：< /u>
根据地理位置，生物模拟市场分为五个关键区域：北美、欧洲、亚太地区、南美和南美。中美洲、中东和非洲非洲。 2022年，北美生物模拟市场在全球生物模拟市场中占据最大份额，预计亚太地区生物模拟市场在预测期内复合年增长率最高。美国生物模拟市场在北美生物模拟市场中占据最大份额。美国已成为领先的临床研究目的地。全球近一半的临床试验在美国进行。
此外，由于美国医疗基础设施完善，大多数制药研究公司更愿意在美国进行临床试验，快速的审批时间表和有利的监管框架。此外，在该国进行的临床试验产生的数据无需经过太多审查即可被全球接受。世界卫生组织（WHO）报告指出，2021年美国注册临床试验数量最多（157,618项）。企业推出的用于临床试验的创新产品进一步推动了美国临床试验市场的增长。 Medical Metrics 是一家为临床试验提供各种服务的临床研究组织 (CRO)，提供“Assessa”产品，该产品可协助药物发现和临床研究的决策过程。它可用于开发治疗神经系统疾病的药物，如痴呆、认知障碍、阿尔茨海默病、精神分裂症和帕金森病。美国临床试验数量的不断增加，有利于该国临床试验市场的增长。
此外，各药企因专利到期而面临利润空间不足的问题，因此，促使制造商开始通过合同研究组织外包这些研究来减少内部研发活动。这使得临床前 CRO 经历了显着的增长。生物技术和制药公司为降低药物开发成本而进行的对抗预计将推动美国生物模拟市场的发展。此外，美国顶级创收制药公司的存在，可以在研发上投入大量资金，预计也将推动美国生物模拟的增长。此外，孤儿病和罕见病领域对服务和药品的需求增长预计将刺激药品制造商通过 CRO 咨询专业疗法和全球站点关系，以帮助他们设计更智能的药品并招募患者进行临床试验。预计该国外包研究的蓬勃发展也将导致行业进入者数量的增加，从而跟上制药和医疗器械行业的快速发展步伐。预计将推动赞助商转向 CRO 的其他几个因素包括获得治疗专业知识、降低固定成本、提高全球影响力、获得公司内部缺乏的创新等等。
行业发展和未来机遇：
主要参与者采取的各种举措全球生物模拟市场如下：
- 2023年3月，Certara发布了最新版本的Simcyp PBPK Simulator Version 22，可以模拟新患者和未测试场景。
- 2023年3月，Simulations Plus Inc.与中美癌症基金会（SACF）建立了战略研究合作。通过此次合作，Simulations Plus 工作人员和 ADMET Predictor 软件平台中的人工智能驱动药物设计 (AIDD) 技术支持 MTHFD2（一种新兴癌症靶点）新型抑制剂的发现和设计。
竞争格局和主要公司：
生物模拟市场的一些领导者包括 Certara、Simulations另外，Dassault Simulation、Advanced Chemistry Development、Genedata AG、VeriSIM Life、Schrödinger, Inc.、Physiomics、Instem Group of Companies 和 Applied BioMath LLC。这些公司专注于产品发布和地域扩张，以满足全球日益增长的消费者需求，并扩大其专业产品组合的产品范围。这些公司在全球范围内拥有广泛的影响力，这使他们能够为大量客户提供服务，从而增加他们的市场份额。该报告提供了生物模拟市场的趋势分析，强调了市场动态、技术进步以及全球领先市场参与者的竞争格局分析等各种参数。
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
This text is related
to segments covered.
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
This text is related
to country scope.
The List of Companies
1. Simulations Plus
2. Certara USA, Inc.
3. Schrödinger, LLC
4. Dassault Systèmes
5. Rosa & Co., LLC
6. Genedata AG
7. Leadscope, Inc.
8. Evidera
9. Advanced Chemistry Development
10. Insilico Biotechnology
11. Chemical Computing Group
12. Certara
13. Physiomics
14. Nuventra Pharma
15. Inosim Software
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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