【研究报告】2022年表观遗传技术市场规模为76.9756亿美元，预计到2030年将达到22、9.2265亿美元；预计 2022 年至 2030 年复合年增长率为 19.20%。
市场洞察和分析师观点：< /strong>
表观遗传学是研究环境因素引起的基因表达变化而不是DNA序列本身的变化。它是指生物体性状的可遗传变化，这些变化独立于其遗传物质而发生。这涉及 DNA 甲基化和组蛋白修饰，可以使用各种技术进行分析。这些变化导致生物体表型而不是基因型的变化，并且它们对于对环境刺激做出反应时的发育至关重要。
推动表观遗传技术市场增长的关键因素包括表观遗传学技术在药物开发中的应用激增，表观遗传学领域的研究和开发的资金、投资和批准不断增加。然而，基于表观遗传学的诊断的标准化和经验丰富的从业人员的缺乏预计将阻碍市场扩张。
战略见解
增长动力和限制：
表观遗传药物发现领域为检测新型治疗药物提供了多种可能性。表观遗传药物开发的目标是非编码 RNA 表达、DNA 甲基化和组蛋白修饰。表观遗传机制对于基因转录、维持基因组稳定性以及促进正常细胞生长、发育和分化非常重要。然而，表观遗传失调可导致多种人类疾病的发生和进展，如癌症、心血管疾病、代谢疾病和神经系统疾病。根据世界卫生组织 (WHO) 的数据，2021 年，癌症导致近 1000 万人死亡，占死亡人数的六分之一。最常见的癌症包括乳腺癌、肺癌、结肠癌、直肠癌和前列腺癌。表观遗传学是一个具有前景的工具领域，可以用于预防、诊断和治疗等多种目的；通过开发针对负责调节基因表达的特定表观遗传机制的药物，可以有效地应用表观遗传工具来治疗包括癌症在内的各种疾病。根据美国癌症协会2022年12月发表的文章，表观遗传修饰，特别是DNA甲基化和组蛋白标记模式的变化，在肿瘤进展和转移中发挥着至关重要的作用。这些癌症特异性事件已被证明是诊断、监测和确定治疗方案以协助临床决策的有用工具。此外，与遗传变化的不可逆性相比，表观遗传机制具有逆转修饰的能力，使其成为药物开发的有吸引力的目标。
此外，采用高通量技术，将下一代测序（NGS）和质谱（MS）纳入临床实验室，以及表观遗传生物标志物的开发，将有助于引入新的基于表观遗传学的体外诊断（IVD）测试，从而扩大其临床应用。根据 ScienceDirect 2021 年发表的一篇文章，两种基于 PCR 的互补策略，例如甲基化敏感技术和甲基化特异性技术。还开发了富集测定法来识别低丰度甲基化或非甲基化 DNA，可用于无创血液检测。
因此，癌症和遗传性疾病病例的增加反过来，导致了用于药物发现和开发以治疗这些疾病的各种表观遗传学技术的研究和开发的兴起。
此外，表观遗传学在非疾病领域的应用越来越多-传染病和自身免疫性疾病的药物开发等肿瘤学应用以及不断增长的定制治疗患者库为该行业提供了盈利潜力；因此，大公司有一个巨大的表观遗传学市场机会可以投资。
然而，基于表观遗传学的诊断的标准化问题和经验丰富的从业人员的缺乏预计将阻碍市场的发展扩展。
市场范围和细分
全球表观遗传学技术市场根据以下因素进行细分：类型、组件、应用程序、技术、最终用户和地理位置。表观遗传学技术市场根据类型分为 NGS、PCR 和 QPCR、质谱、超声处理等。表观遗传学技术市场根据产品和服务的组成部分分为两部分。根据应用，市场分为肿瘤学、代谢疾病、免疫学、心血管疾病等。根据技术，市场分为 DNA 甲基化、组蛋白修饰和非编码 RNA 调节。根据最终用户，市场分为合同研究组织、学术和研究机构以及制药和生物技术行业。表观遗传学技术市场根据地理位置分为北美（美国、加拿大和墨西哥）、欧洲（德国、法国、意大利、英国、俄罗斯和欧洲其他地区）、亚太地区（澳大利亚、中国） 、日本、印度、韩国和亚太地区其他地区）、中东和非洲非洲（南非、沙特阿拉伯、阿联酋以及中东和非洲其他地区）以及南美和非洲中美洲（巴西、阿根廷以及南美洲和中美洲其他地区）。
细分分析：
表观遗传学技术市场按类型分为 NGS、PCR 和 QPCR、质谱、超声处理， 和别的。 NGS 在 2022 年占据最大的市场份额，预计 2022 年至 2030 年市场复合年增长率最高。下一代测序 (NGS) 是一种强大的测序技术，具有高通量、可扩展性和速度。该技术用于确定整个基因组或 DNA 或 RNA 特定区域的核苷酸顺序。 NGS 彻底改变了生物科学，使研究人员能够执行广泛的应用并以前所未有的水平研究生物系统。
表观遗传学技术市场（按应用划分） ; 2022 年和 2030 年
表观遗传学技术市场根据产品和服务的组成部分分为两部分。产品部分进一步细分为酶、仪器、试剂盒和试剂。同样，服务部分进一步分为 ChIP-Seq、CUT&Tag、DNA 甲基化测序、ATAC-Seq、基因表达、染色质结构图谱、IP 质谱和单细胞服务。服务细分市场在 2022 年占据最大的市场份额，而产品细分市场预计在 2022-2030 年期间将实现最高的复合年增长率。
根据应用，市场细分为肿瘤学、代谢疾病、免疫学、心血管疾病等。肿瘤学领域在 2022 年拥有最大的表观遗传学技术市场。然而，预计心血管领域在 2022-2030 年期间将实现最高的复合年增长率。据世界卫生组织称，心血管疾病（CVD）每年导致 1790 万人死亡，原因是不良的生活方式选择，如不健康的饮食、缺乏运动、吸烟和过量饮酒。根据《欧洲预防心脏病学杂志》2022 年 8 月发表的一篇文章，CVD 通常受到遗传性基因变异的影响。某些危险因素，如血脂异常、高血压、糖尿病和肥胖，也与遗传特征有关。研究人员已经发现了数百个与冠状动脉疾病相关的单核苷酸多态性 (SNP)。尽管如此，这些 SNP 只能解释 CVD 遗传性的一小部分，表明基因-基因相互作用和/或表观遗传机制比遗传变异贡献更大。实验证据支持表观遗传变化与 CVD 风险之间存在密切联系。
根据技术，市场分为 DNA 甲基化、组蛋白修饰和非编码 RNA 调节。 2022年至2030年，DNA甲基化细分市场将占据最高的市场份额。
根据最终用户，市场分为医院和诊所、学术和研究机构以及制药和医疗机构。生物技术产业。由于生物技术研究和政府投资的增加，学术和研究机构将在 2022 年占据重要的市场份额。然而，预计 2022 年至 2030 年期间，制药和生物技术行业领域的复合年增长率将是市场上最高的。
区域分析：
根据地理位置，全球表观遗传技术市场分为五个关键区域：北美、欧洲、亚太地区、南美洲和中美洲以及中东和非洲。由于癌症患病率和医疗保健成本上升，预计北美在 2022 年至 2030 年将占据更大的市场份额。北美表观遗传技术市场分为美国、加拿大和墨西哥。市场增长归因于持续的药物开发研究、先进的表观遗传学产品的可用性以及技术先进的医疗保健系统等各种因素导致的临床试验数量的增加。美国已成为领先的临床研究目的地。
行业发展和未来机遇：
全球表观遗传技术市场主要参与者采取的各种举措如下：
- 2023 年 11 月，QIAGEN推出了微生物组 WGS SeqSets，这是一个全面且用户友好的工作流程，用于高效且可重复的微生物组研究。该工作流程简化了样品提取和下一代测序 (NGS) 文库制备以及用户友好的生物信息学分析，使非专家的分析变得更加容易。
- 2023 年 11 月，EpiCypher 推出了全自动 CUT& ;RUN 检测称为 autoCUT&RUN，可实现高通量染色质特征映射。该技术是表观基因组分析领域的重大突破，因为它基于 EpiCypher 业界领先的 CUTANA CUT&RUN 试剂盒。 autoCUT&RUN 检测可实现规模化研究，推进治疗开发和生物标志物发现。
- 2023 年 4 月，更名为 Biomodal 的 Cambridge Epigenetix 推出了新的二重多组学解决方案，结合了来自单个小体积样品。 Duet 多组学解决方案是首个单碱基分辨率测序技术，允许使用当前的测序设备和单一程序同时定相读取单个样本中的基因组和表观遗传信息。
- 在2021 年 9 月，Active Motif 与 Proteintech Group 合作。 Active Motif 获得了 Proteintech Group 的投资，Proteintech Group 是一家抗体、纳米抗体和重组蛋白的原始制造商。 Active Motif 宣布计划利用这笔资金增强其研发能力并扩大其商业范围。通过 Proteintech 作为战略合作伙伴，该公司将获得现金增长、获得高质量抗体以及扩大的分销网络。
- 2022 年 4 月，领先的高品质抗体生产商 PacBio -高质量、高精度测序系统、改变游戏规则的 Sequel IIe 和 Sequel II 系统以及 DNA 甲基化检测功能。 PacBio 独特且高效的 HiFi 测序方法包括访问表观基因组，这是由于标准测序技术固有的局限性而经常被忽视的第二层基因组信息。
竞争格局和主要公司：
Illumina Inc.、BioRad Laboratories、QIAGEN NV、Thermo Fisher Scientific Inc.、Abcam Plc、PerkinElmer、 Inc.、Agilent Technologies Inc.、Zymo Research Corporation、Merck Millipore、Active Motif, Inc. 是表观遗传技术市场的知名参与者。这些公司专注于新技术、现有产品的进步和地域扩张，以满足全球不断增长的消费者需求并扩大其专业产品组合的产品范围。
- Historical Analysis (2 Years), Base Year, Forecast (7 Years) with CAGR
- PEST and SWOT Analysis
- Market Size Value / Volume - Global, Regional, Country
- Industry and Competitive Landscape
- Excel Dataset
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
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Regional Scope
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- Illumina Inc.
- BioRad Laboratories
- QIAGEN N.V.
- Thermo Fisher Scientific Inc.
- Abcam Plc
- PerkinElmer, Inc.
- Agilent Technologies Inc.
- Zymo Research Corporation
- Merck Millipore
- Active Motif, Inc.
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
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As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
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Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
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We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
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The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
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We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.
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