微电极阵列体外市场规模预计将从 2023 年的 1796 万美元增至 2031 年的 2567 万美元;预计 2023-2031 年期间市场复合年增长率为 4.6%。微电极阵列技术与器官芯片的整合可能会在未来几年为市场带来新的趋势。
体外微电极阵列市场分析
器官芯片系统旨在利用微流体和工程组织复制人体器官的生理状况。当与微电极阵列技术相结合时,这些系统可以实时监测电活动,从而深入了解器官模型的功能反应。例如,集成微电极阵列的“心脏芯片”可以提供心脏电生理学数据,使研究人员能够评估不同化合物对心律和收缩力的影响方式。这些信息对于了解药物引起的心脏毒性至关重要,这对药物开发构成了重大担忧。例如,2022 年 9 月,神经器官芯片初创公司 NETRI 与 Axion BioSystems 合作,创建了具有高通量微电极阵列的微流体设备。这项先进技术将使神经科学家能够无创地测量复杂体外模型中神经细胞的电活动,从而加速治疗发现。微电极阵列对于该中心的器官芯片研究至关重要,该研究旨在改进生物模型,同时减少动物试验。该研究的重点是用于研究神经退行性疾病的大脑芯片技术、心脏芯片技术和血脑屏障建模。因此,微电极阵列技术与器官芯片设备的集成预计将在未来几年带来市场增长的新趋势。
此外,主要参与者专注于开发具有创新功能的技术先进的微电极阵列,预计将在市场上创造巨大的机会。
体外微电极阵列市场概况
微电极阵列体外市场正在经历显著增长,因为它在研究细胞活动(尤其是神经生物学、心脏病学和药理学)中发挥着关键作用。MEA 由多个排列成网格的微型电极组成,可以实时监测来自细胞的电信号。由于慢性病发病率上升和研究方法的进步,该技术越来越多地用于药物开发、疾病建模和高通量筛选。
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体外微电极阵列市场驱动因素和机遇
日益关注开发动物测试模型的替代品
动物模型在针对人类特定疾病的生物医学研究中被广泛使用。然而,各种药物毒理学研究表明,动物模型并不总是能够预测人类对药物的反应。这是因为与动物相比,人类对药物和毒素的代谢存在很大差异,这使得在实验室啮齿动物等实验模型中研究药物代谢几乎是不可能的。此外,近年来,特别是在欧洲和北美,已经实施了多项法规,限制在研究活动中使用动物。同样,国际反残忍组织和医学实验动物替代基金会是少数反对以动物为基础的研究模型的监管机构。对化学品、化妆品和环境化合物毒性评估的这种严格监管要求推动了微电极阵列在体外测试中的应用。因此,制药和生物技术公司被鼓励实施基于微电极阵列的测试平台来筛选药物的神经毒性和心脏毒性。
微电极阵列系统制造商(例如 BMSEED)提供专有的可拉伸微电极阵列 (sMEA) 和 MASSuRE 平台。使用 sMEA 通过在受控环境中复制类似于体内条件的细胞电气和机械环境,提高了体外实验的有效性。通过为细胞和组织创建仿生环境,sMEA 可以紧密模拟人体,在临床前研究早期提供更准确、与人类相关的数据。这种方法旨在降低人体临床试验的失败率。
因此,对开发研究动物模型替代品的日益关注推动了体外微电极阵列市场的增长。
具有先进功能的微电极阵列
近年来,体外微电极阵列技术取得了重大进展,增强了其研究细胞活动的能力,特别是在神经生物学和心脏病学领域。下面提到了微电极阵列的一些关键改进:
- 3D 制造技术:3D 微电极阵列的开发允许创建更复杂且生理相关的细胞环境。这些阵列更好地复制了组织的自然结构,促进了电极和细胞之间的相互作用。这种增强对于药物开发和疾病建模中的应用至关重要,因为它可以实现高通量筛选检测和实时健康监测。2023 年 1 月,BMSEED 提交了一份非临时专利申请,用于体外研究的 3D 微电极阵列技术。所申请专利的基础技术开发了一种微电极阵列,该阵列具有可调节的 3D 口袋,其中嵌入的电极物理包裹在类器官周围。该阵列将使研究人员能够记录生理完整的类器官大部分表面(估计为 80%)的神经信号。
- 与先进生物传感器的集成:将生物传感器整合到微电极阵列中可增强其功能,从而可以检测和定量分析生物分子和化合物。这种集成将微电极阵列的应用范围扩展到基本细胞记录之外。
- 增强电极设计:电极设计的进步,包括小型化和增加电极密度,使细胞活动记录更加精确。这对于研究复杂的神经网络和心脏组织尤其有益。MicruX Technologies 是一家创新型技术公司,提供基于蜂窝状微结构排列针孔的微电极。这种薄膜具有一个工作电极,该电极带有一个传感器,该传感器涂有包含 5 µm 或 10 µm 针孔的光刻胶,可形成超微电极阵列。
因此,预计先进微电极阵列的推出将为预测期内在体外微电极阵列市场运营的制造商提供丰厚的增长机会。
体外微电极阵列市场报告细分分析
有助于得出微电极阵列体外市场分析的关键部分是产品、应用和地理。
- 根据产品,体外微电极阵列市场细分为经典 MEA、多孔 MEA 和 CMOS-ME。2023 年,多孔 MEA 部分占据体外微电极阵列市场的最大份额。
- 根据应用,市场分为心肌细胞、神经和其他。2023 年,心肌细胞部分占据体外微电极阵列市场的最大份额。
- 根据地域,市场分为北美、欧洲、亚太、中东和非洲、南美和中美。2023 年,北美占据体外微电极阵列市场的最大份额。
体外微电极阵列市场份额按地区分析
微电极阵列体外市场报告的地理范围主要分为五个主要区域:北美、欧洲、亚太地区、中东和非洲以及南美和中美。北美在 2023 年占据了市场主导地位。投资者越来越关注生产用于体外研究的高通量微电极阵列的公司,这是研究机构、制药行业和生物技术领域的关键要求。基于 CMOS 的微电极阵列、干细胞研究、神经假体和体外毒理学测试的创新正在推动对微电极阵列的需求。2020 年 6 月,佐治亚州立大学研究基金会获得美国国家科学基金会 1.9756 亿美元的资助,用于其项目,该项目涉及开发用于 SARS-CoV-2 和其他 RNA 病毒的微电极阵列传感器。该项目为测量科学提供了一个独特的机会,可以通过创新研究来应对社会和全球危机。
由于神经科学和生物医学研究的进步以及政府的支持性政策,加拿大的微电极阵列体外市场正在经历增长。微电极阵列在记录和刺激神经活动方面起着关键作用,因此在学术和临床环境中必不可少。加拿大最近的创新包括改进微加工技术和开发可增强微电极阵列灵敏度和功能的新材料。加拿大的大学和研究中心正在引领微电极阵列技术的发展。研究人员,尤其是多伦多大学等机构的研究人员,正在将生物传感器与微电极阵列相结合,以更好地检测生物分子,这对于药物开发和疾病治疗至关重要。阿尔伯塔大学利用微电极阵列研究神经元行为和药物相互作用,以增强对神经系统疾病和潜在治疗方法的理解。加拿大政府通过资助计划支持微电极阵列的开发,例如加拿大卫生研究院 (CIHR) 提供的资助,这些资助为微电极阵列相关的神经科学项目提供资助。这项资助促进了学术界和产业界的合作,弥合了研究和实际应用之间的差距。
体外微电极阵列市场区域洞察
Insight Partners 的分析师已详细解释了预测期内影响体外微电极阵列市场的区域趋势和因素。本节还讨论了北美、欧洲、亚太地区、中东和非洲以及南美和中美洲的体外微电极阵列市场细分和地理位置。
- 获取体外微电极阵列市场的区域特定数据
体外微电极阵列市场报告范围
报告属性 | 细节 |
---|---|
2023 年的市场规模 | 1,796万美元 |
2031 年市场规模 | 2567万美元 |
全球复合年增长率(2023 - 2031) | 4.6% |
史料 | 2021-2022 |
预测期 | 2024-2031 |
涵盖的领域 | 按产品
|
覆盖地区和国家 | 北美
|
市场领导者和主要公司简介 |
|
体外微电极阵列市场参与者密度:了解其对业务动态的影响
体外微电极阵列市场正在快速增长,这得益于终端用户需求的不断增长,而这些需求又源于消费者偏好的不断变化、技术进步以及对产品优势的认识不断提高等因素。随着需求的增加,企业正在扩大其产品范围,进行创新以满足消费者的需求,并利用新兴趋势,从而进一步推动市场增长。
市场参与者密度是指在特定市场或行业内运营的企业或公司的分布情况。它表明在给定市场空间中,相对于其规模或总市场价值,有多少竞争对手(市场参与者)存在。
在体外微电极阵列市场运营的主要公司有:
- 塔克戴维斯技术公司
- Screen Holdings 有限公司
- Plexon 公司
- 神经连接
- Neuralynx 公司
免责声明:上面列出的公司没有按照任何特定顺序排列。
- 获取体外微电极阵列市场顶级关键参与者概述
体外微电极阵列市场新闻和最新发展
通过收集一手和二手研究后的定性和定量数据来评估体外微电极阵列市场,其中包括重要的公司出版物、协会数据和数据库。以下列出了市场中的一些发展情况:
- Axion BioSystems 和 STEMCELL Technologies 达成战略合作伙伴关系,这将使 STEMCELL 能够在北美和欧洲销售 Axion 最先进的 Maestro Pro 和 Maestro Edge 多电极阵列系统。业界领先的 Maestro MEA 系统也将继续在全球范围内直接从 Axion BioSystems 购买。(来源:Axion BioSystems,公司网站,2024 年 9 月)
- NETRI 推出了支持 MEA 的器官芯片系列 NeuroFluidics MEA,该系列由三个隔间微流体设备组成,采用 Axion Biosystems 的集成 MEA 技术,并与 Maestro Pro 和 Maestro Edge 系统兼容。(来源:Axion BioSystems,公司网站,2023 年 7 月)
体外微电极阵列市场报告范围和交付成果
“体外微电极阵列市场规模和预测(2021-2031)”报告对以下领域进行了详细的市场分析:
- 范围涵盖的所有主要细分市场的全球、区域和国家层面的体外微电极阵列市场规模和预测
- 微电极阵列体外市场趋势,以及驱动因素、限制因素和关键机遇等市场动态
- 详细的 PEST 和 SWOT 分析
- 微电极阵列体外市场分析涵盖主要市场趋势、全球和区域框架、主要参与者、法规和最新市场发展
- 行业格局和竞争分析,涵盖市场集中度、热图分析、知名参与者以及体外微电极阵列市场的最新发展
- 详细的公司简介
- Historical Analysis (2 Years), Base Year, Forecast (7 Years) with CAGR
- PEST and SWOT Analysis
- Market Size Value / Volume - Global, Regional, Country
- Industry and Competitive Landscape
- Excel Dataset
Report Coverage
Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends
Segment Covered
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Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, South & Central America
Country Scope
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Frequently Asked Questions
North America dominated the market in 2023.
Increasing demand for microelectrode arrays in neuroscience research and rising focus on developing alternatives for animal testing models are among the most significant factors fueling the market growth.
Integration of microelectrode array technologies with organ-on-a-chip is expected to emerge as a prime trend in the market in the coming years.
Tucker Davis Technologies; Screen Holdings Co. Ltd.; Plexon, Inc.; Neuronexus; Neuralynx, Inc.; MaxWell Biosystems AG; Harvard Bioscience, Inc.; Blackrock Microsystems LLC; Axion BioSystems, Inc.; and 3Brain AG are among the key players in the market.
The microelectrode array in vitro market value is expected to reach US$ 25.67 million by 2031.
The market is expected to register a CAGR of 4.6% during 2023–2031.
Trends and growth analysis reports related to Life Sciences : READ MORE..
The List of Companies - Microelectrode Array in Vitro Market
- Tucker Davis Technologies
- Screen Holdings Co. Ltd.
- Plexon, Inc.
- Neuronexus
- Neuralynx, Inc.
- MaxWell Biosystems AG
- Harvard Bioscience, Inc.
- Blackrock Microsystems LLC
- Axion BioSystems, Inc.
- 3Brain AG
The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.
- Data Collection and Secondary Research:
As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.
Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.
- Primary Research:
The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.
For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.
A typical research interview fulfils the following functions:
- Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
- Validates and strengthens in-house secondary research findings
- Develops the analysis team’s expertise and market understanding
Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:
- Industry participants: VPs, business development managers, market intelligence managers and national sales managers
- Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.
Below is the breakup of our primary respondents by company, designation, and region:
Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.
- Data Analysis:
Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.
- Macro-Economic Factor Analysis:
We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.
- Country Level Data:
Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.
- Company Profile:
The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.
- Developing Base Number:
Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.
- Data Triangulation and Final Review:
The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.
We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.
We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.