内瑟顿综合征市场基于(主要地区、市场参与者、规模和份额)- 预测至 2031 年

  • Report Code : TIPRE00013771
  • Category : Life Sciences
  • No. of Pages : 150
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2021 年 Netherton 综合征市场规模为 2115 万美元,预计到 2031 年将从 2023 年的 XX 亿美元增至 1063.4 亿美元。预计 2023-2031 年市场复合年增长率为 20.6%。越来越多的宣传活动、新药上市和强劲的渠道很可能仍是 Netherton 综合征市场的主要趋势。

 

内瑟顿综合症市场分析

内瑟顿综合征 (NS) 是一种多系统遗传性疾病,临床表现为先天性鱼鳞病样红皮病、免疫缺陷和毛干异常等三联征。由于该病的发病机制复杂,目前针对 NS 患者的治疗方法非常有限。由于人们对内瑟顿综合征的认识不断提高,以及产品数量的不断增加,内瑟顿综合征市场正在经历巨大的增长。此外,临床试验数量的不断增加和技术发展为市场参与者的未来增长提供了重要机会。然而,治疗内瑟顿综合征的药物的副作用风险正在阻碍市场的增长。  

 

内瑟顿综合征市场概览

内瑟顿综合征是一种罕见的遗传性疾病,其症状为皮肤鳞屑、毛干异常和易过敏。由于人们的认识提高、基因检测的进步和靶向治疗的发展,内瑟顿综合征市场最近受到了极大的关注。此外,制药公司和研究人员对开发这种罕见遗传性疾病的创新疗法的兴趣日益浓厚,这也推动了市场的发展。

 

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内瑟顿综合征市场:

Netherton Syndrome Market
  • 获取此报告的关键市场趋势。
    这个免费样品将包括数据分析,从市场趋势到估计和预测。

 

内瑟顿综合征市场驱动因素和机遇

 

药品上市数量增加和产品线稳健,利好市场

世界各地的多家公司都致力于推出和开发针对罕见疾病的新型、有效和创新疗法。2020 年 5 月,临床阶段的皮肤科药物制造商 Azitra, Inc. 获得美国食品药品管理局 (FDA) 授予的 ATR-12 罕见儿科疾病称号,用于治疗 Netherton 综合征。2020 年 7 月,Sixera Pharma 开发了一种治疗 Netherton 综合征的方法,专门针对皮肤中的某些蛋白酶。2020 年 5 月,多伦多创新加速合作伙伴 (TIAP)、AmorChem II Fund LP 和 Evotec SE 向一个药物开发项目投资了 175 万美元,该项目重点关注影响全球每 20 万名新生儿中的 1 名的 Netherton 综合征。因此,对 Netherton 综合征治疗和候选药物开发的日益重视预计将促进市场的增长。

 

技术发展的增长——Netherton 综合征市场增长的机会

基因和酶替代疗法等基于致病机制的疗法取得了令人鼓舞的进展。最近对鱼鳞病患者免疫特征的了解也为生物制剂的再利用开辟了新途径。生物疗法包含多种产品,例如针对特定标志物的单克隆抗体,例如肿瘤坏死因子-α (TNF-α)、白细胞介素-13 (IL-13) 和白细胞介素-17 (IL-17)。和白细胞介素-23 (IL-23)。生物制剂在治疗特应性皮炎和牛皮癣等炎症性皮肤病方面拥有丰富的经验。2021 年,一项新的临床试验开始,研究含有 SXR1096 的乳膏在 NS 患者中一个月的使用情况 (NCT05211830)。SXR1096 是 KLK7、KLK5 和 KLK14 的强效抑制剂。 20 名 NS 患者参与了 I/II 期研究,以评估与安慰剂相比的安全性和有效性。大多数参与者专注于发展中市场,例如印度、澳大利亚、中国、沙特阿拉伯和阿联酋,因为这些国家存在患有罕见疾病的患者,并且对临床援助和治疗方案认识的需求不断增加。因此,对新疗法的不断增长的需求为市场参与者创造了增长机会。

 

内瑟顿综合征市场报告细分分析

有助于得出 Netherton 综合征市场分析的关键部分是治疗。

  • 根据治疗方法,内瑟顿综合征市场分为角质溶解剂、生物疗法、口服和外用类固醇和维甲酸、外用钙调磷酸酶抑制剂和放射疗法。角质溶解剂细分市场在 2023 年占据了最大的市场份额,预计同一细分市场在预测期内的复合年增长率最高。

 

内瑟顿综合征市场份额按地区分析

内瑟顿综合征市场报告的地理范围主要分为五个地区:北美、亚太、欧洲、中东和非洲、南美/南美和中美。

北美主导了 Netherton 综合征市场。北美市场的增长归因于该地区 Netherton 综合征的流行。在美国,Netherton 综合征 (NS) 的发病率为每 200,000 个活产婴儿中有 1 至 2 例。由于可能致命的并发症,NS 预后不良,并且在生命最初几年死亡率很高。市场参与者正专注于 Netherton 综合征的药物开发,以应对高发病率。2020 年 4 月,LifeMax Laboratories, Inc. 获得了 FDA 对其用于治疗 Netherton 综合征的候选药物 LM-30 的快速通道指定。2023 年 4 月,总部位于美国的 Quoin Pharmaceuticals 为其正在进行的 II/III 期研究招募了儿科人群,该研究评估了 QRX003 在 Netherton 综合征 (NS) 中的应用。QRX003 是一种广谱丝氨酸蛋白酶抑制剂,可下调皮肤激肽释放酶过度活跃。

 

 

内瑟顿综合征市场区域洞察

Insight Partners 的分析师已详细解释了预测期内影响 Netherton 综合征市场的区域趋势和因素。本节还讨论了 Netherton 综合征市场在北美、欧洲、亚太地区、中东和非洲以及南美和中美洲的细分市场和地理位置。

Netherton Syndrome Market
  • 获取 Netherton 综合征市场的区域特定数据

内瑟顿综合征市场报告范围

报告属性细节
2021 年市场规模2115万美元
2031 年市场规模1063.4亿美元
全球复合年增长率(2023 - 2031)20.6%
史料2021-2022
预测期2024-2031
涵盖的领域通过治疗
  • 角质层剥离剂
  • 口服和外用类固醇和维甲酸
  • 局部钙调磷酸酶抑制剂
  • 放射治疗
  • 生物治疗
覆盖地区和国家北美
  • 我们
  • 加拿大
  • 墨西哥
欧洲
  • 英国
  • 德国
  • 法国
  • 俄罗斯
  • 意大利
  • 欧洲其他地区
亚太
  • 中国
  • 印度
  • 日本
  • 澳大利亚
  • 亚太其他地区
南美洲和中美洲
  • 巴西
  • 阿根廷
  • 南美洲和中美洲其他地区
中东和非洲
  • 南非
  • 沙特阿拉伯
  • 阿联酋
  • 中东和非洲其他地区
市场领导者和主要公司简介
  • Lifemax 实验室有限公司
  • Azitra 公司
  • Sixera制药公司
  • Dermelix 生物治疗公司
  • Matrisys 生物科学
  • Quoin Pharmaceuticals 有限公司
  • Krystal Biotech 公司

 

内瑟顿综合征市场参与者密度:了解其对业务动态的影响

内瑟顿综合征市场正在快速增长,这得益于终端用户需求的不断增长,而这些需求又源于消费者偏好的不断变化、技术进步以及对产品优势的认识不断提高等因素。随着需求的增加,企业正在扩大其产品范围,进行创新以满足消费者的需求,并利用新兴趋势,从而进一步推动市场增长。

市场参与者密度是指在特定市场或行业内运营的企业或公司的分布情况。它表明在给定市场空间中,相对于其规模或总市场价值,有多少竞争对手(市场参与者)存在。

在 Netherton 综合症市场运营的主要公司有:

  1. Lifemax 实验室有限公司
  2. Azitra 公司
  3. Sixera制药公司
  4. Dermelix 生物治疗公司
  5. Matrisys 生物科学
  6. Quoin Pharmaceuticals 有限公司

免责声明上面列出的公司没有按照任何特定顺序排列。


Netherton Syndrome Market

 

  • 获取 Netherton 综合征市场顶级关键参与者概览

 

内瑟顿综合征市场新闻和最新发展

通过收集一级和二级研究后的定性和定量数据来评估 Netherton 综合征市场,其中包括重要的公司出版物、协会数据和数据库。以下是 Netherton 综合征市场的发展列表:

  • MatriSys BioScience 是一家私营临床阶段制药公司,专注于开发用于慢性皮肤病适应症的活生物治疗产品 (LBP),该公司提供了用于治疗 Netherton 综合征的 MSB-2040 的最新动态,该药物正在接受监管申请(美国和欧盟的孤儿药资格认定;IND 和 CTA),并计划在 2023 年下半年对患者启动 1 期研究。(MatriSys BioScience, 新闻, 2023)
  • BioCryst Pharmaceuticals, Inc. 宣布了其药物发现过程的最新进展以及该公司将在研发 (R&D) 上重点介绍的来自其研发管线的其他疗法。BCX17725 是一种强效且选择性的试验性融合蛋白 KLK5 抑制剂,旨在为患有 Netherton 综合征的人提供一流的、可能改善病情的治疗。该公司期待在 2024 年开始 BCX17725 的临床试验。(BioCryst Pharmaceuticals, Inc.,新闻稿,2023 年)
  • 美国国立卫生研究院 (NIH) 授予 ResVita Bio 25 万美元第一阶段 SBIR 资助,用于开发 RVB-001 作为 Netherton 综合征的治疗方法。(ResVita Bio,新闻,2022 年)
  • 细胞疗法初创公司 ResVita Bio 宣布,FDA 授予 RVB-001 罕见儿科疾病认定,用于治疗 Netherton 综合征。RVB-001 是一种基因工程益生菌,局部应用可暂时定植于皮肤并持续释放 LEKTI,从而抑制蛋白水解并恢复表皮屏障的完整性。(ResVita Bio,新闻,2022 年)

 

内瑟顿综合征市场报告覆盖范围和交付成果

“Netherton 综合征市场规模和预测(2021-2031)”报告对市场进行了详细的分析,涵盖以下领域:

  • 范围内所有主要细分市场的全球、区域和国家层面的市场规模和预测
  • 市场动态,如驱动因素、限制因素和关键机遇
  • 未来的主要趋势
  • 详细的 PEST/波特五力分析和 SWOT 分析
  • 全球和区域市场分析涵盖关键市场趋势、主要参与者、法规和最新市场发展
  • 行业格局和竞争分析,涵盖市场集中度、热点图分析、知名参与者和最新发展
  • 详细的公司简介
  • Historical Analysis (2 Years), Base Year, Forecast (7 Years) with CAGR
  • PEST and SWOT Analysis
  • Market Size Value / Volume - Global, Regional, Country
  • Industry and Competitive Landscape
  • Excel Dataset
Report Coverage
Report Coverage

Revenue forecast, Company Analysis, Industry landscape, Growth factors, and Trends

Segment Covered
Segment Covered

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to segments covered.

Regional Scope
Regional Scope

North America, Europe, Asia Pacific, Middle East & Africa, South & Central America

Country Scope
Country Scope

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to country scope.

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The Insight Partners performs research in 4 major stages: Data Collection & Secondary Research, Primary Research, Data Analysis and Data Triangulation & Final Review.

  1. Data Collection and Secondary Research:

As a market research and consulting firm operating from a decade, we have published and advised several client across the globe. First step for any study will start with an assessment of currently available data and insights from existing reports. Further, historical and current market information is collected from Investor Presentations, Annual Reports, SEC Filings, etc., and other information related to company’s performance and market positioning are gathered from Paid Databases (Factiva, Hoovers, and Reuters) and various other publications available in public domain.

Several associations trade associates, technical forums, institutes, societies and organization are accessed to gain technical as well as market related insights through their publications such as research papers, blogs and press releases related to the studies are referred to get cues about the market. Further, white papers, journals, magazines, and other news articles published in last 3 years are scrutinized and analyzed to understand the current market trends.

  1. Primary Research:

The primarily interview analysis comprise of data obtained from industry participants interview and answers to survey questions gathered by in-house primary team.

For primary research, interviews are conducted with industry experts/CEOs/Marketing Managers/VPs/Subject Matter Experts from both demand and supply side to get a 360-degree view of the market. The primary team conducts several interviews based on the complexity of the markets to understand the various market trends and dynamics which makes research more credible and precise.

A typical research interview fulfils the following functions:

  • Provides first-hand information on the market size, market trends, growth trends, competitive landscape, and outlook
  • Validates and strengthens in-house secondary research findings
  • Develops the analysis team’s expertise and market understanding

Primary research involves email interactions and telephone interviews for each market, category, segment, and sub-segment across geographies. The participants who typically take part in such a process include, but are not limited to:

  • Industry participants: VPs, business development managers, market intelligence managers and national sales managers
  • Outside experts: Valuation experts, research analysts and key opinion leaders specializing in the electronics and semiconductor industry.

Below is the breakup of our primary respondents by company, designation, and region:

Research Methodology

Once we receive the confirmation from primary research sources or primary respondents, we finalize the base year market estimation and forecast the data as per the macroeconomic and microeconomic factors assessed during data collection.

  1. Data Analysis:

Once data is validated through both secondary as well as primary respondents, we finalize the market estimations by hypothesis formulation and factor analysis at regional and country level.

  • Macro-Economic Factor Analysis:

We analyse macroeconomic indicators such the gross domestic product (GDP), increase in the demand for goods and services across industries, technological advancement, regional economic growth, governmental policies, the influence of COVID-19, PEST analysis, and other aspects. This analysis aids in setting benchmarks for various nations/regions and approximating market splits. Additionally, the general trend of the aforementioned components aid in determining the market's development possibilities.

  • Country Level Data:

Various factors that are especially aligned to the country are taken into account to determine the market size for a certain area and country, including the presence of vendors, such as headquarters and offices, the country's GDP, demand patterns, and industry growth. To comprehend the market dynamics for the nation, a number of growth variables, inhibitors, application areas, and current market trends are researched. The aforementioned elements aid in determining the country's overall market's growth potential.

  • Company Profile:

The “Table of Contents” is formulated by listing and analyzing more than 25 - 30 companies operating in the market ecosystem across geographies. However, we profile only 10 companies as a standard practice in our syndicate reports. These 10 companies comprise leading, emerging, and regional players. Nonetheless, our analysis is not restricted to the 10 listed companies, we also analyze other companies present in the market to develop a holistic view and understand the prevailing trends. The “Company Profiles” section in the report covers key facts, business description, products & services, financial information, SWOT analysis, and key developments. The financial information presented is extracted from the annual reports and official documents of the publicly listed companies. Upon collecting the information for the sections of respective companies, we verify them via various primary sources and then compile the data in respective company profiles. The company level information helps us in deriving the base number as well as in forecasting the market size.

  • Developing Base Number:

Aggregation of sales statistics (2020-2022) and macro-economic factor, and other secondary and primary research insights are utilized to arrive at base number and related market shares for 2022. The data gaps are identified in this step and relevant market data is analyzed, collected from paid primary interviews or databases. On finalizing the base year market size, forecasts are developed on the basis of macro-economic, industry and market growth factors and company level analysis.

  1. Data Triangulation and Final Review:

The market findings and base year market size calculations are validated from supply as well as demand side. Demand side validations are based on macro-economic factor analysis and benchmarks for respective regions and countries. In case of supply side validations, revenues of major companies are estimated (in case not available) based on industry benchmark, approximate number of employees, product portfolio, and primary interviews revenues are gathered. Further revenue from target product/service segment is assessed to avoid overshooting of market statistics. In case of heavy deviations between supply and demand side values, all thes steps are repeated to achieve synchronization.

We follow an iterative model, wherein we share our research findings with Subject Matter Experts (SME’s) and Key Opinion Leaders (KOLs) until consensus view of the market is not formulated – this model negates any drastic deviation in the opinions of experts. Only validated and universally acceptable research findings are quoted in our reports.

We have important check points that we use to validate our research findings – which we call – data triangulation, where we validate the information, we generate from secondary sources with primary interviews and then we re-validate with our internal data bases and Subject matter experts. This comprehensive model enables us to deliver high quality, reliable data in shortest possible time.