Viral Vector and Plasmid DNA Manufacturing Market Report & Growth Analysis 2027

[Research Report] The viral vector and plasmid DNA manufacturing market size was projected to grow from US$ 459.4 million in 2019 to US$ 2,247.7 million by 2027; it is further estimated to record a CAGR of 22.1% from 2020–2027.

Analyst Perspective:

The increasing demand for gene therapy and advancement in gene editing technologies for the development of treatment option for various chronic disorders, viral infection, and others are driving the viral vector and plasmid DNA manufacturing market growth. Additionally, increase in research activities and growing investments in pharmaceutical & biotechnology industries followed by the favorable regulatory scenario is expected to anticipate the market growth. Moreover, integration of advanced computing technologies is further expected to enhance the application area of viral vector and plasmid DNA manufacturing in near future which in turn propelling the market growth.

Market Overview:

A viral vector is a tool used in gene delivery and manipulation. It is modified virus that has been engineered to carry and deliver specific genes into cells. Viral vectors are commonly used in gene therapy for gene editing application, as they can efficiently deliver genetic material into target cells. Plasmid vector is a small circular piece of DNA that is separate from the chromosomal DNA in a cell. Plasmids can replicate independently and are commonly found in bacteria. In research, plasmids are often used as vectors to introduce genes into cells for various purposes, such as protein production or genetic engineering. Both viral vector and plasmid DNA are essential tools for gene delivery and manipulation in research, allowing researchers to understand potential applications.

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Viral Vector and Plasmid DNA Manufacturing Market: Strategic Insights

Viral Vector and Plasmid DNA Manufacturing Market

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  CAGR (2019 - 2027)

  22.1%
• Market Size 2019
  US$ 459.4 Million
• Market Size 2027
  US$ 2,247.7 Million

Market Dynamics

GROWTH DRIVERS

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FUTURE TRENDS

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OPPORTUNITIES

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Key Players

• Brammer Bio
• Sanofi
• FUJIFILM Diosynth Biotechnologies
• Cell and Gene Therapy Catapult
• Cobra Biologics
• FinVector
• Kaneka Eurogentec S A
• MassBiologics
• Spark Therapeutics

Regional Overview

• North America
• Europe
• Asia-Pacific
• South and Central America
• Middle East and Africa

Market Segmentation

Product

• Viral Vectors and Non-viral Vectors

Application

• Cancer
• Inherited Disorders
• Viral Infections

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Market Trends:

I

ntegration of Advanced Computing Technologies

Emergence of revolutionary technologies such as artificial intelligence, data science, natural language processing, and others are estimated to reshape the future of healthcare technologies during the forecast period. However, gene therapy offers innovative solutions for treatment of diseases, the execution of it faces some technical challenges. For instance, error in gene replacing may lead to harmful mutations in the DNA, resulting into severe health problems. To achieve high level of precision in procedures, intelligent algorithms can offer a significant way. Further, a majority of players are engaged in R&D of new technologies, which will deal with increasing demand for modern technologies. For instance, in March 2019, Oxford Biomedica entered into strategic collaboration with Microsoft to improve gene therapies. Moreover, in May 2020, Dyno Therapeutics announced its proposed financial investments of an estimated US$ 2.0 billion to design AI-based gene therapies. Such events represent a huge opportunity for the integrations of advanced computing technologies, which will eventually redefine the concept of gene therapies during years to come.

Segmental Analysis:

Based on application, the viral vector and plasmid DNA manufacturing market is segmented into cancer, inherited disorders, viral infections, and others. The cancer segment held the largest share of the market in 2019, and the same segment is anticipated to register the highest CAGR of 22.6% during the forecast period. Viral vectors and non-viral vectors have their application and are being studied for both preventive and therapeutic applications in cancer or oncology. Viral vector-based immunization with anticancer agents or delivery of anticancer genes is some critical areas of research that have shown steady progress. Moreover, the government approvals of lentiviral vector-based CAR-T cell therapies, which is used for the treatment of Acute Lymphoblastic Leukemia (ALL) and large B cell lymphoma, have attracted considerable attention from users. Viral vectors and non-viral vectors have resulted in a significant proliferation of the cancer-based pipeline projects on advanced therapies. For instance, around two-thirds of the research in gene therapy is focused on oncology. The above-mentioned factors have contributed to the dominance of cancer over other disease areas. Based on products, the global viral vector and plasmid DNA manufacturing market is bifurcated into viral and non-viral vectors. In 2019, the viral vectors segment held the largest market share, and the same segment is expected to grow at the fastest CAGR during the coming years.

Regional Analysis:

Based on geography, global viral vector and plasmid DNA manufacturing market is segmented into North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America. North America held the largest viral vector and plasmid DNA manufacturing market share which is closely followed by Europe. The US held the largest share of the North American viral vector and plasmid DNA manufacturing market in 2019. The growth of the US market is primarily driven by the growing awareness regarding benefits of gene therapy, increasing research and development activities, and rising demand for advanced therapeutic solutions to treat chronic conditions and viral infections.

In addition, increasing demand for viral vectors due to growing adoption of gene therapies is also anticipated to drive the US viral vector and plasmid DNA manufacturing market growth during the forecast period. In addition, due to this growing demand, major players in the market are focusing on expansion of their viral vector manufacturing capacity. For instance, in May 2020, Thermo Fisher Scientific Inc. announced its plan to expand viral vector manufacturing capacity. According to company estimates, the new facility will be operational by 2022. Further, in April 2020, Merck announced its proposed plan to open a new US-based manufacturing facility for viral vectors. The company has invested around US$ 112.6 million for this proposed expansion.

In Canada, the viral vector and plasmid DNA manufacturing market growth is expected owing to the development of the healthcare systems and rapidly increasing adoption of modern cell related technologies. On the other hand, in Mexico, it is expected that the viral vector and plasmid DNA manufacturing market is likely to experience growth opportunities due increasing awareness of benefits offered by viral vectors and plasmid DNA.

Key Player Analysis:

The viral vector and plasmid DNA manufacturing market majorly consists of the players such as Brammer Bio, Sanofi, Cardinal Health Inc, FUJIFILM Diosynth Biotechnologies, Cell and Gene Therapy Catapult, Cobra Biologics, FinVector, Kaneka Eurogentec SA, MassBiologics, Spark Therapeutics, and Uniqure among others. Among the players in the viral vector and plasmid DNA manufacturing market, Sanofi and FUJIFILM Diosynth Biotechnologies are the top two players owing to their organic and inorganic activities.

Viral Vector and Plasmid DNA Manufacturing Market Report Scope

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Recent Developments: 

Inorganic and organic strategies such as mergers and acquisitions are highly adopted by companies in the viral vector and plasmid DNA manufacturing market. A few recent key market developments are listed below: 

• In March 2023, Sartorius acquired French company Polyplus for 2.4 billion euros ($2.6 billion). The deal gives Sartorius additional know-how in nucleic acid delivery, including transfection reagents and plasmid DNA design, all of which are key elements in the production of viral vectors for building cell and gene therapies.
• In July 2021, Thermo Fisher Scientific Inc. opened a new cGMP plasmid DNA manufacturing facility in Carlsbad, Calif., enabling it to meet rapidly growing demand for plasmid DNA-based therapies and vital mRNA-based vaccines.
• In March 2021, WACKER acquired 100% of the shares in pharmaceutical contract manufacturer Genopis Inc. from Helixmith Co Ltd, Seoul (South Korea) and Medivate Partners LLC, Seoul (South Korea) in February. The signing of the related agreement was followed by the successful closing in late February and, now, the acquisition’s new name: Wacker Biotech US Inc.